Hubungan Kadar Vitamin D Dengan Keluhan Vulvovaginal Atropi Yang Dinilai Dengan Menggunakan Indeks Maturitas Vagina Pada Wanita Menopause

Abstract

Background: Vulvovaginal atrophy (VVA) is a common complaint among postmenopausal women due to estrogen deficiency, leading to dryness, irritation, and discomfort, significantly affecting their quality of life. Recent studies suggest that Vitamin D may play a role in maintaining vaginal epithelial integrity and immune function, but its relationship with VVA remains underexplored. Objective: This study aims to investigate the relationship between serum Vitamin D levels and vulvovaginal atrophy, assessed using the Vaginal Maturity Index (VMI), in postmenopausal women. Methods: This was an observational analytical study with a cross-sectional design conducted at the University of Sumatera Utara Hospital. A total of 32 postmenopausal women were enrolled. Data collection included demographic characteristics, serum Vitamin D levels, and VMI assessment. Statistical analysis was performed using the Spearman correlation test. Results: The mean Vitamin D level among participants was 19.5 ± 5.6 ng/mL, indicating a deficiency. The mean VMI score was 59.16 ± 8.99. A significant positive correlation was found between serum Vitamin D levels and VMI scores (r = 0.610, p = 0.001), suggesting that higher Vitamin D levels were associated with better vaginal epithelial maturity. Conclusion: There is a strong correlation between Vitamin D levels and VMI in postmenopausal women. These findings suggest that Vitamin D may play a role in maintaining vaginal health and could be considered in managing VVA symptoms. Further research is needed to explore Vitamin D supplementation as a potential therapeutic strategy for VVA in postmenopausal women.