Formulasi Sediaan Nanoemulgel Minyak Peppermint (Mentha piperita L.) dan Uji Aktivitas Antibakteri terhadap Propionibacterium acnes

Abstract

Background: Acne is one of the diseases experienced by about 85% of the world's population aged 11-30 years, especially in adolescents aged 15-18 years. One of the natural ingredients that can be used to overcome it is peppermint oil which has antibacterial activity against Propionibacterium acnes. peppermint oil can be formulated into nanoemulgel to facilitate its use. Objective: This study aims to formulate peppermint oil nanoemulgel that meets the physical evaluation requirements of nanoemulgel and observe the antibacterial activity against Propionibacterium acnes. Methods: peppermint oil was formulated with various concentrations of F1 (1%), F2 (2%) and F3 (3%) and then carried out physical evaluation and antibacterial activity testing of peppermint oil nanoemulgel preparations against Propionibacterium acnes. Then physical stability testing at room temperature for 12 weeks, centrifugation test, and cycling test were conducted. Results: peppermint oil nanoemulgel preparations produced are semisolid, milky white in color, and have a distinctive peppermint smell and also meet the evaluation requirements with pH 4.95-6.43, viscosity 12,200-14,720 cPs, and do not cause irritation to the skin. The results of the antibacterial activity test of peppermint oil nanoemulgel preparations against Propionibacterium acnes had an inhibition zone diameter of 13.13-15.3 mm. All nanoemulgel preparations were stable in storage for 12 weeks at room temperature, did not experience phase separation during cycling test, and centrifugation. Conclusion: peppermint oil formulated into nanoemulgel dosage form that meets the physical quality requirements of the preparation and is stable for 12 weeks in room temperature storage and has antibacterial activity against Propionibacterium acnes.