Korelasi Antara Penanda Metabolisme Tulang (Free Deoxypyridinoline) dan Kepadatan Mineral Tulang Dengan Teknologi Rems (Radiofrequency Echographic Multi-Spectrometry) pada Wanita Pascamenopause

Abstract

Background: The menopausal transition (MT) is a critical period of bone strength change in women, setting the stage for the development of osteoporosis and fracture susceptibility in older age. BMD begins to decline approximately 1 year before FMP, and continues to decline in early postmenopause, with a slight decrease in the rate of loss approximately 2 years after FMP. Evaluation of free deoxypyridinoline levels in osteoporosis patients is essential because increased free deoxypyridinoline indicates demineralization that can reduce bone mass. Bone densitometry assessment with radiofrequency echographic multi spectrometry (REMS) is a new ultrasound-based technique that can reliably assess BMD at the lumbar spine, femoral neck, and hip. The use of REMS has been validated in postmenopausal osteoporosis and has been approved as a possible alternative to DXA Methods: This study is an observational analytical study with cross-sectional data collection. The subjects of the study were 32 postmenopausal women who examined Bone Metabolism Markers (free deoxypyridinoline) using elisa which were then examined for Bone Mineral Density with REMS (Radiofrequency Echographic Multi-Spectrometry) Technology and compared. Results: In predicting osteoporosis in postmenopausal women is 63.8% with a p value = 0.299 and 95% IK 36.7% - 90.9%. This shows that DPD levels cannot be used to predict osteoporosis in postmenopausal women. The composition of deoxypyridinoline ranges from 21% of the total cross-linking in bones. Approximately 40-50% of cross-linking is present during the formation of 30-40% with a number of small peptides, cross-linked telopeptide (N-telopeptides and Ctelopeptides) in addition to the TRAP enzyme and calcium, as a biochemical marker substance for resorption or bone remodeling. The sensitivity value in the study is related to the theory that the composition of deoxypyridinoline is only around 21% during bone remodeling. Conclusion: There was no significant correlation between DPD levels and bone mineral density. This indicates that DPD levels cannot be used to predict osteoporosis in postmenopausal women.