| dc.description.abstract | Background: Kemuning leaves (Murraya paniculata L.) contain flavonoids
compounds that have activity as antioxidants. Formulation of ethanol extract of
kemuning leaves in the form of effervescent tablets can maximize the potential of
traditional medicine, with the practical advantage of being easy to consume because
it dissolves quickly in water so as to increase the absorption of drugs by the body.
Objective: To formulate the ethanol extract of kemuning leaves in the form of
effervescent tablets, prove whether the effervescent tablet preparation meets the
evaluation requirements, and determine the effect of variations in the concentration
of kemuning leaf extract on the effectiveness of antioxidants using the DPPH
method.
Method: Extraction of kemuning leaves was carried out by maceration method
using 70% ethanol solvent, then phytochemical screening and characterization of
simplisia and ethanol extract of kemuning leaves were carried out. Furthermore,
antioxidant activity testing of ethanol extract of kemuning leaves was carried out
using the DPPH silencing method by UV-Vis spectrophotometry. Effervescent
tablets were formulated using wet granulation method with variations in extract
concentrations of 50 mg (F1); 100 mg (F2); and 150 mg (F3). The effervescent
tablets obtained were tested for physical quality evaluation including weight
uniformity test, size uniformity test, friability test, hardness test, dissolution time
test and pH test. Furthermore, the antioxidant activity of effervescent tablets was
tested using the DPPH inhibition method by UV-Vis spectrophotometry.
Results: Ethanol extract of kemuning leaves has antioxidant activity with a very
strong category, with an IC50 value of 26,75 µg/mL. All effervescent tablet formulas
met the quality requirements with an average weight of 2,98-2,99 mg; thickness
between 0,719-0,72 cm and diameter between 1,97-1,98 cm; friability between
0.53%-0.65%; hardness between 5,62-6,14 kg; dissolving time between 119-153,66
seconds and pH between 6,05-6,27. Antioxidant activity of effervescent tablets of
ethanol extract of kemuning leaves with IC50 values of 138,4 µg/mL (F1); 96,64
µg/mL (F2); 76,14 µg/mL (F3).
Conclusion: Ethanol extract of kemuning leaves has antioxidant activity with a
very strong category and can be formulated into effervescent tablet preparations that
meet quality evaluation requirements. Effervescent tablets of kemuning leaf extract
have moderate to strong antioxidant activity with 150 mg kemuning leaf extract
formula (F3) as the most optimal formula. | en_US |
