Korelasi Nilai Mean Platelet Volume dan Immature Platelet Fraction dengan Agregasi Trombosit pada Pasien Sindrom Koroner Akut yang Menjalani Intervensi Koroner Perkutan

Abstract

BACKGROUND: Platelet activation during the acute phase of acute coronary syndrome (ACS) stimulates the bone marrow to release immature, larger, and more reactive platelets into circulation. mean platelet volume (MPV) and immature platelet fraction (IPF) are thought to reflect platelet activity, however the relationship between these parameters and platelet aggregation function remains unclear, particularly in patients who have undergone percutaneous coronary intervention (PCI). AIM: To analyze the associatiom between MPV and IPF with platelet aggregation in ACS patients undergoing PCI. METHODS: This analytical observational study involved 33 ACS patients undergoing PCI. MPV and IPF were measured using an automated hematology analyzer. Platelet aggregation was assessed using light transmission aggregometry (LTA) with ADP at concentrations of 1, 2, 5, and 10 μM. Aggregation was classified as hypo-, normo-, and hyperaggregation. Statistical analyses were performed using ANOVA, Kruskal-Wallis, and Fisher's exact test. RESULTSs: The majority of subjects were male (90.9%), with a mean age of 54.3±11.6 years. 75.8% were diagnosed with STEMI. The median IPF was 2.7%; the mean MPV was 9.6 fL. The majority (90.9%) were classified as hypoaggregative. No significant differences were found in MPV and IPF based on diagnosis, therapy, or aggregation status. The Fisher exact test showed no significant association between MPV or IPF and platelet aggregation (p>0.05). CONCLUSION: MPV and IPF are not associated with platelet aggregation in patients with ACS after PCI. Direct evaluation of platelet function remains necessary to assess response to antiplatelet therapy. Keywords: MPV, IPF, Platelet Aggregation, Acute Coronary Syndrome, Percutaneous Coronary Intervention