Uji Experimental Pemberian Vitamin D terhadap Kadar Kortisol Saliva pada Wanita Pascamenopause

Abstract

Background: Menopause marks a major transition in a woman's life. The definition of menopause is 12 months of amenorrhea or the cessation of menstrual periods without other causes. Menopause is associated with problematic symptoms, including hot flashes, sleep problems, mood disorders, sexual dysfunction, genitourinary dysfunction, weight gain, and cognitive decline. Stress is closely related to the HPA axis and the adrenal glands as the organs that secrete the hormone cortisol. Vitamin D supplementation has been used for the treatment of menopausal disorders including stress reduction. Methods : Quasi experimental was conducted in the LK study group in Medan Johor District, Kwala Bekala Village from April 2025 to Mei 2025. 32 menopausal women were divided equally into 2 groups of vitamin D administration with doses of 1000 IU and 2000 IU. Serum Vitamin D levels and morning salivary cortisol levels before and after administration were examined in the laboratory. Results: The 1000 IU group before vitamin D administration (p = 0.123, r = 0.402), and after vitamin D administration (p = 0.231 r = -0.317) and the 2000 IU group, the results did not show a significant correlation between vitamin D serum levels and salivary cortisol before vitamin D administration (p = 0.252 r = -0.304), and after vitamin D administration (p = 0.495, r = -0.184). Although there is a tendency for a negative correlation, these results are not strong enough to conclude a significant statistical relevance. Conclusion: In the administration of vitamin D dose 1000 IU, there was no significant relationship between vitamin D levels and salivary cortisol levels either before or after supplementation. Although there was a tendency for a negative correlation, this result was not strong enough to conclude that there was a statistically significant relationship. Although statistically the difference in the distribution of DASS categories was not strong enough to reach the level of significance, clinically it showed a trend of increasing benefits of the 1000 IU dose in improving psychological symptoms compared to the 2000 IU dose.