Hubungan Kadar PLCR Dan IPF Dengan Troponin I Pada Pasien SKA Di RS Adam Malik

Abstract

Background : Troponin I is a cardiac myocyte necrosis biomarker with higher sensitivity and specificity than Creatine Kinase Myocardial Band (CK-MB) in diagnosing acute coronary syndrome (ACS). However, cardiac biomarker test is expensive and not available in all regions of Indonesia. Platelet Large Cell Ratio (P-LCR) and Immature Platelet Fraction (IPF) are platelet indices that reflect the presence of young platelets in circulation. Increased P-LCR and IPF may indicate platelet consumption during ACS events and have the potential to serve as diagnostic adjuncts. Objective : To determine the relationship between P-LCR and IPF levels with Troponin I levels in patients diagnosed with ACS at Adam Malik Hospital. Methods This observational study used a cross-sectional design involving 51 patients diagnosed with ACS, who underwent measurement of Troponin I, P-LCR, and IPF between February and March 2025. Data were analyzed using the Spearman correlation and Chi-square tests. Results : A total of 51 patients were included, with a predominance of male patients (32 individuals; 62.7%). The mean age was 60.5 ± 1.4 years. ST-elevation myocardial infarction (STEMI) was diagnosed in 22 patients (43.1%), and 76.5% (39 patients) had elevated Troponin I levels. The mean P-LCR was 32.69 ± 8.67%, and the mean IPF was 3.65 ± 2.05%. A significant relationship was found between P-LCR and Troponin I levels (p=0.026). No significant relationship was observed between IPF and Troponin I levels (p=0.093). The correlation between P-LCR and Troponin I was positive but weak (r=0.2–0.39). Conclusion : There is a statistically significant positive correlation between increased P-LCR and Troponin I levels in ACS patients, although the strength of the correlation is weak.