Hubungan Kadar Vitamin D Total dan Platelet Count terhadap Sindrom Depresif pada Pasien Systemic Lupus Erythematosus di RSUP. H. Adam Malik Medan

Abstract

Correlation of Total Vitamin D Levels and Platelet Count with Depressive Syndrome in Patients with Systemic Lupus Erythematosus at H. Adam Malik General Hospital Medan Beby Puteri Utami1, Mustafa Mahmud Amin2, Vita Camellia3 Psychiatric Department Faculty of Medicine Universitas Sumatera Utara Abstract Background : Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease characterized by immune dysregulation and multisystem involvement. In addition to clinical manifestations, SLE patients frequently experience psychiatric problems, particularly depressive syndromes, which can worsen quality of life and treatment adherence. Biological factors are thought to play a role in the development of depressive disorders in SLE patients, including vitamin D deficiency, which is associated with immune dysregulation and central nervous system inflammation. Furthermore, alterations in platelet count in SLE are not only linked to disease activity but may also influence neuroimmunological mechanisms contributing to depression. This study aimed to analyze the association between total vitamin D levels and platelet count with depressive syndrome in patients with SLE. Methods : This cross-sectional correlational study involved 89 patients diagnosed with SLE. Serum total vitamin D levels and platelet counts were measured through blood analysis, while depressive syndrome was assessed using the Patient Health Questionnaire-9 (PHQ-9). Correlation analysis was conducted to determine the association between vitamin D levels, platelet count, and depressive syndrome. Results : The study discovered that total vitamin D levels (r = -0.642, p < 0.05) and platelet count (r = -0.646, p < 0.05) were negatively correlated with depressive syndrome. The median age of participants was 32 years, with 94.4% being female and a median disease duration of 2 years. The median PHQ-9 score was 11, the median platelet count was 145,000, and the median vitamin D level was 19.20 ng/mL. Conclusion : Vitamin D deficiency and reduced platelet count are significantly associated with depressive syndrome in SLE patients. These findings suggest that vitamin D and platelet count may serve as accessible biomarkers for early detection of depression in SLE, and further studies are warranted to investigate their potential as therapeutic targets. Keywords : Systemic Lupus Erythematosus, Biomarker, Vitamin D, Platelet, Depressive Syndrome