Analisis Hubungan Kadar Vitamin D Total Dan Laju Endap Darah Terhadap Sindrom Depresif Pada Pasien Rheumatoid Arthritis

Abstract

Background: Rheumatoid Arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation that can damage joints and extra-articular organs. RA is characterized by a progressive disease that has detrimental psychological effects, such as depression. Depression in RA is influenced by the patient's physical symptoms, such as fatigue, pain, stiffness, and impaired physical function. RA patients are more susceptible to anxiety, depression, and cognitive impairment compared to the general healthy population. Many studies have found a significant correlation between Vitamin D levels and tissue inflammation scores with depression in RA patients. Methods: Samples were collected using a non-probability consecutive sampling method, with a total sample size of 76 RA patients. The Pearson and Spearman correlation tests were used in this study. Results: The majority of subjects were female, at 66 (86.8%), with a median age of 50.5 years. The highest number of subjects were unemployed and had a high school education, at 54 (71.1%) and 55 (72.4%), respectively. The highest number of subjects were married, at 64 (84.2%), with 36 (47.4%) having moderate disease activity. ESR levels and depressive syndrome were positively correlated with an r value of 0.604, while Vitamin D and depressive syndrome were negatively correlated with an r value of -0.743. Conclusion: This study found a relationship between Vitamin D levels and ESR values and depressive syndrome in RA patients. Keywords: Depressive syndrome, Vitamin D, Erythrocyte Sedimentation Rate (ESR), Rheumatoid Arthritis