| dc.description.abstract | Background. Sepsis neonatorum is a serious blood infection in newborns, mainly affecting
premature or low birth weight infants. Early detection is tough, but new research suggests
platelet indices could help diagnose it faster. Methods. This was an observational analytical
study with a retrospective cohort design conducted at Adam Malik Hospital. A total of 115
suspected neonatal sepsis samples were enrolled. Data collection included demographic
characteristics, platelet count, mean platelet volume (MPV), and platelet distribution width
(PDW). Statistical analysis was performed using receiver operator curve (ROC) to assess the
diagnostic value of platelet indices (platelet, MPV, and PDW). Results. The study involved
115 newborns suspected of neonatal sepsis, with 46.1% male and 53.9% female. Most were
delivered via cesarean section and diagnosed with early onset sepsis. Common clinical signs
included respiratory distress and distension. Key risk factors included prolonged rupture of
membranes and low birth weight. Blood culture revealed Klebsiella pneumonia as the most
common pathogen. Platelet indices showed varied sensitivity and specificity as predictors of
sepsis. Conclusions. Diagnostic tests had low sensitivity but varied specificity for detecting
sepsis with platelet count, MPV, and PDW.
Keyword: Platelet, Marker, MPV, PDW, Neonatal Sepsis | en_US |
