Perbedaan Kadar Hepcidin pada Preeklamsia dan Hamil Normal Trimester 3 di RSP Prof. Dr. Chairuddin Panusunan Lubis Universitas Sumatera Utara

Abstract

Background. Preeclampsia (PE) is a pregnancy disorder due to endothelial dysfunction and placental vasospasm after 20 weeks of gestation. In normal pregnancy, hepcidin levels will decrease as the pregnancy progresses. However, a complex picture has also been observed in PE in terms of hepcidin concentration. Hepcidin, an iron-regulating hormone, is elevated in PE and plays a role in inflammatory responses as well as oxidative stress. Evaluation of hepcidin levels in PE is important to understand the body's protective mechanisms against inflammation in this condition.

Objective: To determine the correlation between hepcidin levels in preeclampsia and normal pregnancy.

Methods: A case-control design involved 15 normal pregnant women with PE each. Mean hepcidin levels were analyzed to determine correlation.

Results: The average hepcidin level in PE was 16.18 ± 7.13 ng/dL while in normal pregnant 3.15 ± 2.33 ng/dL. Using the Mann Whitney test showed that there was a significant difference in hepcidin levels (p<0.001) between pregnant women with PE and normal pregnant women.

Conclusion: The mean hepcidin level is higher in PE women than normal pregnant women, so there is a significant difference in hepcidin levels between pregnant women with preeclampsia and normal pregnant women. Hepcidin examination can be used as one of the examinations to predict the incidence of PE.

Keywords: Normal Pregnancy, Hepcidin, Preeclampsia, Diagnosis