Akurasi Neutrophil Gelatinase-Associated Lipocalin (NGAL) dalam Mendiagnosis Acute Kidney Injury (AKI) pada Anak

Abstract

Acute Kidney Injury (AKI) is a common clinical finding that produces some serious health problems. For the previous decades, the identification of AKI clinical practically based on laboratory test as Blood Urea Nitrogen (BUN) and Serum Creatinin (SC). Unfortunately, SC is not a reliable indicator of AKI in the acute phase. Neutrophil Gelatinase-Associated Lipocalin (NGAL) is promisingly an early biomarker of ischemic kidney injury. After performing the inclusion criteria and exclusion criteria, samples undergo the operation then admitted to the ICU ward. Samples were followed and underwent serially laboratory examination of urine NGAL, SC and urine output according to the timetable of the research. Mean concentration of SC before operation and hour 0 hour, 6 hours, and 24 hours after operation for non AKI patients were as follow 0.83 ± 0.19 mg/dl; 0.83 ± 0.19 mg/dl; 0.89 ± 0.18 mg/dl; and 0.88 ± 0.25 mg/dl. And for AKI patients were 0.86 ± 0.21; 0.81 ± 0.20 mg/dl; 1.01 ± 0.20 mg/dl; and 1.84 ± 0.75 mg/dl. Mean concentration of urine NGAL on 0 hours, 3 hours, and 6 hours post-operation non AKI patients were as follows 26.0 ± 27.7 ng/l; 24.4 ± 23.0 ng/l; and 32.6 ± 42.4 ng/l. While in AKI patients were 809.4 ± 379.0 ng/l; 732.0 ± 450.0 ng/l; and 651.4 ± 432.0 ng/l. The elevated concentration of urine NGAL among cases of AKI occurred earlier than the elevated concentration of SC.