Evaluasi Reakssi Obat Tidak Diinginkan dan Kualitas Hidup Pasien Kanker yang Menjalani Kemoterapi

Abstract

Background: Chemotherapy is a key treatment in cancer therapy, but it is frequently accompanied by Adverse Drug Reactions (ADRs), which may affect patients’ physical and psychological well-being. ADRs such as nausea, vomiting, dizziness, and fatigue can reduce treatment adherence and negatively impact quality of life (QoL). Objective: To assess the occurrence of ADRs in cancer patients undergoing chemotherapy and to evaluate the relationship between ADRs and their quality of life. Methods: This was a quantitative observational study with a cross-sectional design involving 77 cancer patients undergoing chemotherapy at RSUP Prof. dr. Chairuddin P. Lubis. Data were collected using the ADR questionnaire and EQ-5D- 5L quality of life instrument. Statistical analysis was performed using Spearman’s correlation test. Results: A total of 87% of patients experienced ADRs, with the most frequent being drowsiness (11.7%), dizziness (10.9%), nausea and vomiting (10.6%), and anxiety (10.2%). In terms of QoL, 26% of patients reported a very good quality of life, 32.5% good, 19.5% moderate, and 22.1% poor. Statistical analysis showed a positive but non-significant correlation between ADRs and QoL (r = -0,141; p = 0,221). Conclusion: While most cancer patients undergoing chemotherapy experienced multiple ADRs, these reactions did not show a statistically significant impact on their quality of life. Continuous monitoring and proper management of ADRs are essential to support patients’ overall well-being during treatment.