| dc.description.abstract | Background: Chemotherapy is a key treatment in cancer therapy, but it is
frequently accompanied by Adverse Drug Reactions (ADRs), which may affect
patients’ physical and psychological well-being. ADRs such as nausea, vomiting,
dizziness, and fatigue can reduce treatment adherence and negatively impact quality
of life (QoL).
Objective: To assess the occurrence of ADRs in cancer patients undergoing
chemotherapy and to evaluate the relationship between ADRs and their quality of
life.
Methods: This was a quantitative observational study with a cross-sectional design
involving 77 cancer patients undergoing chemotherapy at RSUP Prof. dr.
Chairuddin P. Lubis. Data were collected using the ADR questionnaire and EQ-5D-
5L quality of life instrument. Statistical analysis was performed using Spearman’s
correlation test.
Results: A total of 87% of patients experienced ADRs, with the most frequent being
drowsiness (11.7%), dizziness (10.9%), nausea and vomiting (10.6%), and anxiety
(10.2%). In terms of QoL, 26% of patients reported a very good quality of life, 32.5%
good, 19.5% moderate, and 22.1% poor. Statistical analysis showed a positive but
non-significant correlation between ADRs and QoL (r = -0,141; p = 0,221).
Conclusion: While most cancer patients undergoing chemotherapy experienced
multiple ADRs, these reactions did not show a statistically significant impact on
their quality of life. Continuous monitoring and proper management of ADRs are
essential to support patients’ overall well-being during treatment. | en_US |
