Uji In Silico Kandungan Senyawa Bunga Telang (Clitoria ternatea) yang Berpotensi sebagai Anti Aging

Abstract

Background: Skin aging is a complex biological process caused by internal and external factors that lead to the decline of skin cells and function. Oxidative stress plays a key role by upregulating MMP-9 through the activation of AP-1 and proinflammatory cytokines, which accelerates dermal tissue degradation. Excessive MMP activity damages the extracellular matrix, degrades collagen and elastin, and inhibits procollagen biosynthesis. Therefore, MMP inhibition is a potential strategy in anti-aging therapy to maintain skin structure and function. Objectives: To learn the potential of butterfly pea flower (Clitoria ternatea) compounds against skin aging in MMP-9 receptors in silico. Methods: Biological activity prediction using PASS Online, predicting physicochemical properties using the Lipinski rule of five test, in silico docking using Autodock vina application, and visualization analysis of docking results using Discovery Studio. Results: All compounds contained in butterfly pea flowers have biological activity as antioxidants. Forty-seven test compounds were obtained that met the Lipinski rules of five test, and naringin was found to have the lowest binding affinity value of -12.1 ± 0.9711 kcal/mol through the docking process with the Autodock vina application. Naringin has 1 hydrophobic interaction, 4 hydrogen bonds, and 11 van der Waals bonds through visualization with Discovery Studio. Conclusion: The compounds contained in butterfly pea flowers (Clitoria ternatea) have the potential to act as anti-aging agents for the skin through the MMP-9 receptor, which is indicated by hydrophobic interaction bonds (PHE (110)), hydrogen bonds (ALA (191)) and van der Waals (LEU (187), HIS (411), GLU (111), GLU (402), HIS (190), HIS (405)), as well as lower binding affinity values than the comparison compounds.