Pengaruh Pemberian Infiltrasi Ropivacaine 0,5% pada Luka Operasi terhadap Perubahan Kadar Glukosa Darah dan Nilai Numeric Rating Scale (NRS) Pasca Operasi Lumbal

Abstract

Background: The increasing prevalence of spinal surgery can lead to postoperative pain, triggering stress responses and elevating blood glucose levels, which in turn affects treatment outcomes. Postoperative pain management, such as with Ropivacaine infiltration, is important for reducing stress responses and stabilizing glucose levels. This study aimed to examine the effects of Ropivacaine on changes in blood glucose levels and pain levels after spinal surgery. Methods: This research employed a randomized controlled trial design to observe the effects of 0.5% ropivacaine infiltration on blood glucose levels and pain scores following spinal surgery, conducted in several hospitals in the city of Medan. Patients with diabetes, heart/kidney/adrenal issues, ropivacaine hypersensitivity, or chronic steroid/opioid use were excluded. Participants were recruited through sequential sampling and randomized to ropivacaine infiltration or a control group, with drop-out criteria including intraoperative death or postoperative intubation. Results were considered significant if p < 0.05. Results: In this study, 19 subjects (67.9%) were male and 9 (32.1%) were female, with a mean age of 54.96 years (SD = 7.62). The mean NRS scores were compared between the infiltration and non-infiltration groups. At T1, the infiltration group had a mean NRS of 2.21 (SD = 0.57), while the non-infiltration group had a mean of 4.71 (SD = 0.72), indicating a significant difference (p < 0.001). Postoperative blood glucose levels did not significantly differ between the ropivacaine infiltration and non-infiltration groups. Conclusion: In this study, there was no significant difference in random blood sugar levels either preoperatively or postoperatively in the two different groups. There was a difference in NRS values in the group of ropivacaine administration by infiltration into the surgical wound and without infiltration, where the group of ropivacaine administration had a lower NRS value. Keywords: Spinal surgery, Ropivacaine, blood glucose level, numeric rating scale