Browsing Doctoral Dissertations by Submit Date
Now showing items 1-20 of 183
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Hubungan Antara Polimorfisme Gen Hormon Luteinizing Hormone Beta (LHβ) Rs1056917, Follicle Stimulating Hormone Beta (FSHβ) Rs6169, dan Fat Mass And Obesity Associated (FTO) Rs9939609 dengan Sindroma Ovarium Polikistik (SOPK)
(Universitas Sumatera Utara, 2025-07)Introduction: Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder associated with ovarian dysfunction, insulin resistance, and obesity. Genetic factors, particularly the LH-β, FSH-β, and FTO genes, play a key ... -
Peran Propolis Sebagai Induktor Apoptosis pada Sel Osteosarkoma (U2OS) Melalui Ekspresi BCL-2, BAX, DAN CASPASE-3 In-Vitro
(Universitas Sumatera Utara, 2025)Introduction: Propolis, as a natural product with antitumor properties, is considered to have potential as an apoptotic agent against osteosarcoma cells through the regulation of Bcl-2, Bax, and caspase-3 expression, but ... -
Pengaruh Ekstrak Ginkgo Biloba terhadap Perubahan MnSOD dan IL8 pada Pasien Retinopati Diabetik Non-Proliferatif pasca Terapi Intravitreal Ranibizumab
(Universitas Sumatera Utara, 2025)Background: Diabetic retinopathy (DR) is a major complication of diabetes mellitus (DM) and a leading cause of vision loss in working-age adults. Oxidative stress and inflammation play critical roles in DR pathogenesis, ... -
Pengaruh Pemberian Sekretom Sel Punca Mesenkimal Hipoksia pada Tikus Galur Wistar Model Stroke Iskemik Kajian pada Evaluasi Defisit Neurologis, Vascular Endothelial Growth Factor, Glial Fibrillary Acidic Protein, CD31 dan S100b
(Universitas Sumatera Utara, 2025)Introduction: Currently, the standard treatments for ischemic stroke are intravenous thrombolysis and endovascular recanalization. In the acute phase (<4.5 hours), only 3.2 % to 5.2% of ischemic stroke patients are ... -
Peran Kombinasi Ivermektin dan Deksametason dalam Menginduksi Apoptosis melalui BAX, BCL-2 dan Caspase-3 pada Sel Leukemia Limfoblastik Akut
(Universitas Sumatera Utara, 2025)Introduction: The development of glucocorticoid resistance has complicated the management of acute lymphoblastic leukemia (ALL), leading to increased mortality rates. Ivermectin, a low-cost and well-established anthelmintic, ... -
Efek Thymoquinone terhadap Ekspresi Faktor Transkripsi p63, Claudin dan Periostin pada Hewan Model Rinosinusitis Kronik dengan Polip Hidung
(Universitas Sumatera Utara, 2025)Introduction: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic condition of the nasal mucosa and paranasal sinuses, involving epithelial barrier dysfunction, chronic inflammation, and tissue remodeling. Tight ... -
Peran Sel Punca Mesenkimal dalam Meregulasi Sel Dendritik, Th1, Th2, dan CD19+CD5+ CD1dhi Sel B pada Pasien Lupus Eritematosus Sistemik
(Universitas Sumatera Utara, 2025)Background: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by chronic inflammation affecting multiple organs. This disease exhibits high variability in disease progression and prognosis ... -
Efek Ekstrak Daun Semanggi Merah (Trifolium pratense) Terhadap Neurogenesis Serebral Melalui Modulasi Brain Derived Neurotrophic Factor dan Glial Cell Line-Derived Neurotrophic Factor Pada Tikus Galur Sprague-Dawley Model Penyakit Parkinson
(Universitas Sumatera Utara, 2025)Introduction: Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta caused by multifactorial factors. However, until now, the administration ... -
Peran Probiotik dalam Mempengaruhi Kadar Short-Chain Fatty Acids (SCFA), Penanda Inflamasi (Interleukin 6, Interleukin 10 dan C-Reactive Protein) serta Gambaran Histopatologi Alveolar Mencit Model Penyakit Paru Obstruktif Kronik
(Universitas Sumatera Utara, 2024)Introduction: Systemic inflammation that occurs in chronic obstructive pulmonary disease (COPD) results in multimorbidity and decreased quality of life of patients. However, current standard treatment with inhaled ... -
Pengaruh Pola Genomik Methicillin-resistant Staphylococcus aureus (MRSA) dan Methicillin-susceptible Staphylococcus aureus (MSSA) terhadap Implikasi Klinis Pasien di Rumah Sakit Umum Pusat H. Adam Malik Medan
(Universitas Sumatera Utara, 2024)Background: Staphylococcus aureus is a pathogen with significant clinical impact. Its strains are classified based on their resistance status into Methicillin-resistant Staphylococcus aureus (MRSA) and Methicillin-susceptible ... -
Hubungan Karakteristik Genetik SARS-CoV-2 dan Polimorfisme rs2074192 Gen ACE2 serta rs12329760 Gen TMPRSS2 terhadap Luaran dan Derajat Penyakit sebagai Prediktor Keparahan Covid-19
(Universitas Sumatera Utara, 2024)Background: COVID-19 has caused dramatic number of infections and deaths worldwide. Its pathogenesis of severity was not fully recognized. ACE2 and TMPRSS2 act as the receptors and molecules whose responsible for virus ... -
Pengembangan Model Prediksi Kegawatan dan Mortalitas pada Anak dengan Covid-19 Berbasis Aplikasi Digital
(Universitas Sumatera Utara, 2024)Background: During the COVID-19 pandemic, the mortality rate of children with COVID-19 in Indonesia is higher than the neighboring countries in Asia or the Southeast Asian region. In the other side, limited health facilitis ... -
Pengaruh Vitamin D terhadap Respons Terapi pada Anak Epilepsi Resisten Obat melalui Modulasi Jalur Glial Cell Line-Derived Neurotrophic Factor dan Interleukin-1β
(Universitas Sumatera Utara, 2024)Introduction. Drug-Resistant Epilepsy (DRE) is defined as failure of two anti-epileptic drugs (AEDs) to control seizures continuously. Vitamin D could be alternative therapy by increasing GDNF and decreasing IL-1β, but ... -
Hubungan Antara Panjang Telomere Leukosit dengan Fungsi Kognitif dan Keparahan Gejala pada Penderita Skizofrenia Suku Batak
(Universitas Sumatera Utara, 2024)Background: A number of studies have shown evidence of shortening of leukocyte telomere length among people with schizophrenia. Telomere shortening has been associated with acceleration of the biological aging process of ... -
Potensi Sampo Ekstrak Bunga Telang (Clitoria Ternatea) sebagai Anti Dandruff: Kajian Biomolekuler, Imunopatogenesis dan Klinis
(Universitas Sumatera Utara, 2024)Introduction: Dandruff is a scalp disorder characterized by the presence of scales on the scalp and hair shafts accompanied by minimal inflammation and itching. The pathogenesis of dandruff is still a mystery, excessive ... -
Efek Pemberian Ekstrak Propolis terhadap Edema dan Inflamasi Serebri Akibat Perdarahan Intraserebral Spontan pada Rattus Novergicus Galur Sprague Dawley
(Universitas Sumatera Utara, 2024)Introduction. Intracerebral hemorrhage induced secondary brain injury i.e edema and inflammation that caused irreversible brain damage. Extract propolis has been proved for strong antiinflammation and antioxidant and also ... -
Pengaruh Penghambatan Jalur PI3K/AKt/mTOR pada Sel Kanker Kolorektal WiDr dengan Pemberian Kombinasi Propolis, 5-Fluorourasil dan Oksaliplatin
(Universitas Sumatera Utara, 2024)Background: The incidence of colorectal cancer continues to rise, with the majority of patients developing metastases. Chemotherapy, including the use of cytostatics, presents challenges due to the emergence of chemoresistance. ... -
Pengaruh Ekstrak Daun Puguntano (Picria fel-terrae Merr.) terhadap PI3k, VEGF, Interleukin – 6, PSA, Indeks Prostat dan Histopatologi Prostat pada Tikus Obesitas dengan Benign Prostat Hiperplasia
(Universitas Sumatera Utara, 2024)Background: Benign Prostate Hyperplasia (BPH) is a disease that often occurs in elderly men and has a serious impact on public health. Obesity is one of the main factors that increase the risk of chronic non-communicable ... -
Hubungan Polimorfisme Gen SLC39A14 rs4872479 G/T dengan Tinggi Badan dan Kualitas Hidup Melalui Analisis Kadar Zink Serum, Insulin-Like Growth Factor-1 pada Anak Sindrom Nefrotik
(Universitas Sumatera Utara, 2024)Background. Nephrotic syndrome (NS) is a chronic kidney disease that is often found in children with corticosteroids as one of the managements given. The long-term impact of chronic disease conditions and corticosteroid ... -
Efek Ekstrak Etanol dan Air Daun Belalai Gajah (Clinacanthus Nutans) terhadap Ekspresi Protein P53 Mouse Double Minute 2 Homolog dan AKt pada Sel Punca Kanker Payudara
(Universitas Sumatera Utara, 2024)Background: Breast cancer is the most common cancer among women in Indonesia with the number of new cases reaching 48,998. The advancement of medical technology in the implementation of cancer patients has not been able ...