Browsing Doctoral Dissertations by Issue Date
Now showing items 1-20 of 194
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Pengembangan Instrumen Penilaian Afasia dalam Bahasia Indonesia melalui Pendekatan Korelasi Network Bahasa pada Primary Progressive Aphasia
(Universitas Sumatera Utara, 2026-01-09)Background: Primary Progressive Aphasia (PPA) is a neurodegenerative syndrome characterized by progressive impairment of language, with substantial implications for patient care, early intervention, and long-term management. ... -
Pengaruh Pemberian Ekstrak Kulit Buah Manggis (Garcinia Mangostana L) Terhadap Marker Inflamasi, Eritropoietin dan Gambaran Histopatologi Ginjal Tikus Wistar Model Penyakit Ginjal Kronik
(Universitas Sumatera Utara, 2026)Chronic Kidney Disease (CKD) is a global health problem whose prevalence continues to increase, with a global prevalence of 10%. Most CKD patients exhibit a chronic inflammatory state with elevated levels of inflammatory ... -
Efek Ekstrak Daun Semanggi Merah (Trifolium pratense) Terhadap Neurogenesis Serebral Melalui Modulasi Brain Derived Neurotrophic Factor dan Glial Cell Line-Derived Neurotrophic Factor Pada Tikus Galur Sprague-Dawley Model Penyakit Parkinson
(Universitas Sumatera Utara, 2025)Introduction: Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta caused by multifactorial factors. However, until now, the administration ... -
Peran Sel Punca Mesenkimal dalam Meregulasi Sel Dendritik, Th1, Th2, dan CD19+CD5+ CD1dhi Sel B pada Pasien Lupus Eritematosus Sistemik
(Universitas Sumatera Utara, 2025)Background: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by chronic inflammation affecting multiple organs. This disease exhibits high variability in disease progression and prognosis ... -
Efek Thymoquinone terhadap Ekspresi Faktor Transkripsi p63, Claudin dan Periostin pada Hewan Model Rinosinusitis Kronik dengan Polip Hidung
(Universitas Sumatera Utara, 2025)Introduction: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic condition of the nasal mucosa and paranasal sinuses, involving epithelial barrier dysfunction, chronic inflammation, and tissue remodeling. Tight ... -
Peran Kombinasi Ivermektin dan Deksametason dalam Menginduksi Apoptosis melalui BAX, BCL-2 dan Caspase-3 pada Sel Leukemia Limfoblastik Akut
(Universitas Sumatera Utara, 2025)Introduction: The development of glucocorticoid resistance has complicated the management of acute lymphoblastic leukemia (ALL), leading to increased mortality rates. Ivermectin, a low-cost and well-established anthelmintic, ... -
Pengaruh Pemberian Sekretom Sel Punca Mesenkimal Hipoksia pada Tikus Galur Wistar Model Stroke Iskemik Kajian pada Evaluasi Defisit Neurologis, Vascular Endothelial Growth Factor, Glial Fibrillary Acidic Protein, CD31 dan S100b
(Universitas Sumatera Utara, 2025)Introduction: Currently, the standard treatments for ischemic stroke are intravenous thrombolysis and endovascular recanalization. In the acute phase (<4.5 hours), only 3.2 % to 5.2% of ischemic stroke patients are ... -
Pengaruh Ekstrak Ginkgo Biloba terhadap Perubahan MnSOD dan IL8 pada Pasien Retinopati Diabetik Non-Proliferatif pasca Terapi Intravitreal Ranibizumab
(Universitas Sumatera Utara, 2025)Background: Diabetic retinopathy (DR) is a major complication of diabetes mellitus (DM) and a leading cause of vision loss in working-age adults. Oxidative stress and inflammation play critical roles in DR pathogenesis, ... -
Peran Propolis Sebagai Induktor Apoptosis pada Sel Osteosarkoma (U2OS) Melalui Ekspresi BCL-2, BAX, DAN CASPASE-3 In-Vitro
(Universitas Sumatera Utara, 2025)Introduction: Propolis, as a natural product with antitumor properties, is considered to have potential as an apoptotic agent against osteosarcoma cells through the regulation of Bcl-2, Bax, and caspase-3 expression, but ... -
Hubungan Antara Polimorfisme Gen Hormon Luteinizing Hormone Beta (LHβ) Rs1056917, Follicle Stimulating Hormone Beta (FSHβ) Rs6169, dan Fat Mass And Obesity Associated (FTO) Rs9939609 dengan Sindroma Ovarium Polikistik (SOPK)
(Universitas Sumatera Utara, 2025)Introduction: Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder associated with ovarian dysfunction, insulin resistance, and obesity. Genetic factors, particularly the LH-β, FSH-β, and FTO genes, play a key ... -
Efek Salinomycin Dibandingkan Doxorubicin serta Kombinasinya sebagai Inhibitor Multidrug Resistance dan Sebagai Regulator Apoptosis pada Kultur Sel Osteosarkoma (U2OS) Invitro: Evaluasi Terhadap Ekspresi Gen Bcl2, Gen Bax, Gen P-glycoprotein, NF-κB, dan IκBα
(Universitas Sumatera Utara, 2025)Background: Osteosarcoma is a primary bone malignancy often resistant to chemotherapy, primarily due to overexpression of P-glycoprotein (Pgp). This study aims to evaluate the effects of salinomycin, compared to doxorubicin ... -
Efek Curcuminoid terhadap Kadar HIF-1α, VEGF, H2O2, Histopatologi Organ Corti, dan SNR pada Rattus norvegicus Model Diabetes Mellitus
(Universitas Sumatera Utara, 2025)Background: Patients with Diabetes Mellitus (DM) are at high risk of experiencing hearing impairment. Cellular response to hypoxic conditions in DM involves an increase in Hypoxia-Inducible Factor-1 (HIF-1) levels. One of ... -
Model Prediktif Tinggi Badan dengan Variabel Metacarpal untuk Identifikasi Post Mortem Kasus Kedokteran Forensik
(Universitas Sumatera Utara, 2025)Background: The incidence of disasters has tended to increase over the past twenty years. These events have claimed many lives and require accurate identification processes. Forensic identification uses comparisons of ... -
Peran Ekstrak Andaliman (Zanthoxylum Acanthopodium DC) terhadap Kadar Plasminogen Aktivator Inhibitor – 1 (PAI - 1), Pentraxin 3 (PTX 3), Nitric Oxide (NO) dan Gambaran Histopatologi Arteri Spiralis Tikus Model Preeklamsia
(Universitas Sumatera Utara, 2025)Introduction: Pregnancy-related hypertension is a major factor in the development of preeclampsia, a disorder characterized by impaired trophoblast invasion into the spiral arteries, placental hypoxia or ischemia, and ... -
Pengaruh Penggunaan Hidrogel Ekstrak Kemenyan Toba (Styrax sumatrana J.J. Sm.) terhadap Penyembuhan Luka, Ekspresi IL-6, TGF-β1, dan FGF-2 pada Kelinci Putih Model Luka Bakar
(Universitas Sumatera Utara, 2025)Background: Burn wound are a common problem in society, especially in poor and developing countries. In Indonesia, burn wound account for 1.3% and in Sumatera Utara about 1.04%. Traditional burn treatment using herbal ... -
Efek Fitoestrogen Red Clover (Trifolium Pratense) terhadap Modulasi Interleukin-1β, Interleukin-10, Tumor Necrosis Factor-Α Dan Proses Neurogenesis pada Tikus Galur Sprague Dawley Model Stroke Iskemik
(Universitas Sumatera Utara, 2025)Introduction: Stroke occurs due to focal or global disturbances of brain function caused by vascular disorders. However, pharmacological approaches to treat ischemic stroke remain limited. Red clover ( Trifolium pratense ... -
Pengaruh Kombucha Biji Pinang (Areca Catechu) terhadap Mikrobiota Usus dan Bio-Penanda Inflamasi Mencit Tua
(Universitas Sumatera Utara, 2025)Background: Aging is associated with chronic low-grade inflammation, known as inflammaging. This condition is characterized by elevated levels of pro- inflammatory cytokines, such as IL-6 and TNF-α, which contribute to ... -
Pengaruh Pemberian Ekstrak Kulit Buah Manggis (Garcinia Mangostana L) terhadap Marker Inflamasi, Eritropoietin dan Gambaran Histopatologi Ginjal Tikus Wistar Model Penyakit Ginjal Kronik
(Universitas Sumatera Utara, 2025)Chronic Kidney Disease (CKD) is a global health problem whose prevalence continues to increase, with a global prevalence of 10%. Most CKD patients exhibit a chronic inflammatory state with elevated levels of inflammatory ... -
Hubungan Kadar Zink Serum, Zinc Superoxide Dismutase (ZnSOD), Metallothionein, dan Poliformisme Gen Metallothionein 1A rs8052394 dengan Derajat Distres Pernapasan pada Bayi Baru Lahir dengan Usia Kehamilan 28 – 34 Minggu
(Universitas Sumatera Utara, 2025)Backround: Respiratory distress is one of the leading causes of admission to the Neonatal Intensive Care Unit (NICU), particularly among preterm infants with a gestational age of less than 34 weeks. The incidence of ... -
Pengaruh Tetes Mata Curcumin terhadap Penyembuhan Luka Laserasi Lamellar Kornea Ditinjau dari Penurunan Ekspresi IL-1, TNF-α, NFκB serta Perbaikan Gambaran Histopatologi Kornea Rattus Norvegicus
(Universitas Sumatera Utara, 2024)Backgroung Corneal lamellar lacerations are emergencies in ophthalmology that involve partial thickness of the cornea. Curcumin is a polyphenol derived from Rhizopus which has the ability to accelerate wound healing Purpose To ...