Browsing Doctoral Dissertations by Issue Date
Now showing items 1-20 of 177
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Efek Ekstrak Daun Semanggi Merah (Trifolium pratense) Terhadap Neurogenesis Serebral Melalui Modulasi Brain Derived Neurotrophic Factor dan Glial Cell Line-Derived Neurotrophic Factor Pada Tikus Galur Sprague-Dawley Model Penyakit Parkinson
(Universitas Sumatera Utara, 2025)Introduction: Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta caused by multifactorial factors. However, until now, the administration ... -
Peran Sel Punca Mesenkimal dalam Meregulasi Sel Dendritik, Th1, Th2, dan CD19+CD5+ CD1dhi Sel B pada Pasien Lupus Eritematosus Sistemik
(Universitas Sumatera Utara, 2025)Background: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by chronic inflammation affecting multiple organs. This disease exhibits high variability in disease progression and prognosis ... -
Pengaruh Tetes Mata Curcumin terhadap Penyembuhan Luka Laserasi Lamellar Kornea Ditinjau dari Penurunan Ekspresi IL-1, TNF-α, NFκB serta Perbaikan Gambaran Histopatologi Kornea Rattus Norvegicus
(Universitas Sumatera Utara, 2024)Backgroung Corneal lamellar lacerations are emergencies in ophthalmology that involve partial thickness of the cornea. Curcumin is a polyphenol derived from Rhizopus which has the ability to accelerate wound healing Purpose To ... -
Peran Polimorfisme E670G (rs505151) Gen PCSK9 dan Perbandingan antara Kadar PCSK9 terhadap Severitas Lesi Koroner pada Penderita Penyakit Jantung Koroner
(Universitas Sumatera Utara, 2024)Background: Cardiovascular disease, the most prevalent health issue globally, continues to escalate in both developed and developing nations. A notable method for assessing the risk of coronary artery disease (CAD) involves ... -
Pengaruh Metamizole terhadap Kadar IL-18, NGAL, Myeloperoxidase dan Gambaran Histopatologi pada Tikus Wistar Model Renal Ischemia-Reperfusion Injury
(Universitas Sumatera Utara, 2024)Background: Renal ischaemia-reperfusion injury (RIRI) is a common kidney procedure complication due to temporary blood flow interruption, leading to kidney injuries. This study aimed to analyze the effect of metamizole ... -
Pengaruh Fraksi Etil Asetat dari Ekstrak Bawang Dayak (Eleutherine bulbosa (Mill.) Urb) terhadap Sel Kanker Payudara T47D yang Dipaparkan Estrogen
(Universitas Sumatera Utara, 2024)Background: Breast cancer is the most common cause of cancer death in women and the fifth leading cause of all cancer deaths. In Indonesia, the high incidence of breast cancer is also accompanied by a low rate of treatment ... -
Pengaruh Pemberian Kombinasi Ekstrak Gambir (Uncaria gambier Roxb) dan Angiotensin Receptor Blocker (ARB) terhadap Kadar Transforming Growth Factor-Beta (TGF- β), Ekspresi Nadph Oxidase 4 (NOX4) aan Derajat Glomerulosklerosis pada Tikus Galur Wistar Model Sindrom Nefrotik
(Universitas Sumatera Utara, 2024)Background: Nephrotic syndrome (NS) is the most common glomerular disease found in children. Proteinuria induces profibrotic and proinflammatory cytokines that play a role in extracellular matrix synthesis, differentiation, ... -
Hubungan Sel Eosinophil dan Massa Eosinophil dengan Keberadaan Atypical Mycobacterium pada Biopsi Aspirasi Lymphadenitis
(Universitas Sumatera Utara, 2024)Background. The diagnosis of tuberculous lymphadenitis on aspiration biopsy preparations can be established based on the presence of dark specks (DS). DS is rather dark-colored stuff contained in eosinophilic granular ... -
Hubungan Polimorfisme Gen SLC39A14 rs4872479 G/T dengan Tinggi Badan dan Kualitas Hidup Melalui Analisis Kadar Zink Serum, Insulin-Like Growth Factor-1 pada Anak Sindrom Nefrotik
(Universitas Sumatera Utara, 2024)Background. Nephrotic syndrome (NS) is a chronic kidney disease that is often found in children with corticosteroids as one of the managements given. The long-term impact of chronic disease conditions and corticosteroid ... -
Pengaruh Ekstrak Daun Puguntano (Picria fel-terrae Merr.) terhadap PI3k, VEGF, Interleukin – 6, PSA, Indeks Prostat dan Histopatologi Prostat pada Tikus Obesitas dengan Benign Prostat Hiperplasia
(Universitas Sumatera Utara, 2024)Background: Benign Prostate Hyperplasia (BPH) is a disease that often occurs in elderly men and has a serious impact on public health. Obesity is one of the main factors that increase the risk of chronic non-communicable ... -
Efek Pemberian Piracetam pada Kadar dan Ekspresi Interleukin-6, Glial Fibrillary Acidic Protein, Brain-Derived Neurotrophic Factor, mRNA Gelsolin, mRNA GluN3A, dan mRNA Calmodulin-2, pada Jaringan Otak Janin Tikus Model Periventricular Leukomalacia
(Universitas Sumatera Utara, 2024)Introduction: Periventricular leukomalacia (PVL) is commonly found in cases of hypoxic ischemic encephalopathy, occurring due to perinatal damage to the cerebral cortex. This damage may be in the form of hypoxia, metabolic ... -
Hubungan dan Rasio Partikulat Mater 10 terhadap Metilasi DNA Gen p53 dan Jumlah Black Dots dalam Nuklei Sel Epitel Bukal Pekerja Daur Ulang Tempat Pembuangan Akhir Sampah Kota Medan
(Universitas Sumatera Utara, 2024)Open landfill sites are frequently-exposed areas of particulate matter (PM10) with various types of particulates. This variation is due to the waste disposal management activity including burning, fermentations, movements ... -
Efek Ekstrak Etanol dan Air Daun Belalai Gajah (Clinacanthus Nutans) terhadap Ekspresi Protein P53 Mouse Double Minute 2 Homolog dan AKt pada Sel Punca Kanker Payudara
(Universitas Sumatera Utara, 2024)Background: Breast cancer is the most common cancer among women in Indonesia with the number of new cases reaching 48,998. The advancement of medical technology in the implementation of cancer patients has not been able ... -
Pengaruh Penghambatan Jalur PI3K/AKt/mTOR pada Sel Kanker Kolorektal WiDr dengan Pemberian Kombinasi Propolis, 5-Fluorourasil dan Oksaliplatin
(Universitas Sumatera Utara, 2024)Background: The incidence of colorectal cancer continues to rise, with the majority of patients developing metastases. Chemotherapy, including the use of cytostatics, presents challenges due to the emergence of chemoresistance. ... -
Efek Pemberian Ekstrak Propolis terhadap Edema dan Inflamasi Serebri Akibat Perdarahan Intraserebral Spontan pada Rattus Novergicus Galur Sprague Dawley
(Universitas Sumatera Utara, 2024)Introduction. Intracerebral hemorrhage induced secondary brain injury i.e edema and inflammation that caused irreversible brain damage. Extract propolis has been proved for strong antiinflammation and antioxidant and also ... -
Potensi Sampo Ekstrak Bunga Telang (Clitoria Ternatea) sebagai Anti Dandruff: Kajian Biomolekuler, Imunopatogenesis dan Klinis
(Universitas Sumatera Utara, 2024)Introduction: Dandruff is a scalp disorder characterized by the presence of scales on the scalp and hair shafts accompanied by minimal inflammation and itching. The pathogenesis of dandruff is still a mystery, excessive ... -
Peran Probiotik dalam Mempengaruhi Kadar Short-Chain Fatty Acids (SCFA), Penanda Inflamasi (Interleukin 6, Interleukin 10 dan C-Reactive Protein) serta Gambaran Histopatologi Alveolar Mencit Model Penyakit Paru Obstruktif Kronik
(Universitas Sumatera Utara, 2024)Introduction: Systemic inflammation that occurs in chronic obstructive pulmonary disease (COPD) results in multimorbidity and decreased quality of life of patients. However, current standard treatment with inhaled ... -
Pengaruh Vitamin D terhadap Respons Terapi pada Anak Epilepsi Resisten Obat melalui Modulasi Jalur Glial Cell Line-Derived Neurotrophic Factor dan Interleukin-1β
(Universitas Sumatera Utara, 2024)Introduction. Drug-Resistant Epilepsy (DRE) is defined as failure of two anti-epileptic drugs (AEDs) to control seizures continuously. Vitamin D could be alternative therapy by increasing GDNF and decreasing IL-1β, but ... -
Pengembangan Model Prediksi Kegawatan dan Mortalitas pada Anak dengan Covid-19 Berbasis Aplikasi Digital
(Universitas Sumatera Utara, 2024)Background: During the COVID-19 pandemic, the mortality rate of children with COVID-19 in Indonesia is higher than the neighboring countries in Asia or the Southeast Asian region. In the other side, limited health facilitis ... -
Hubungan Antara Panjang Telomere Leukosit dengan Fungsi Kognitif dan Keparahan Gejala pada Penderita Skizofrenia Suku Batak
(Universitas Sumatera Utara, 2024)Background: A number of studies have shown evidence of shortening of leukocyte telomere length among people with schizophrenia. Telomere shortening has been associated with acceleration of the biological aging process of ...