Browsing Doctoral Dissertations by Type "Disertasi Doktor"
Now showing items 1-20 of 174
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Adenomatous Polyposis Coli, Mismatch Repair dan Instabilitas Mikrosatelit Kanker Kolorektal Berdasarkan Perbedaan Lokasi antara Kolon Proksimal, Distal dan Rektum
(Universitas Sumatera Utara, 2013)Background: In Western countries most of colorectal cancer (CRC) cases are found in the colon (proximal and distal) rather than in the rectum. Each location can result in defferent clinical, pathological and molecular ... -
Akurasi Pewarnaan Histokimia Nucleolar Argyrophilic Organizing Regions (AgNORs) dan Ki-67 untuk Membedakan Lesi Jinak, Premalignan dan Malignan Jaringan Prostat
(Universitas Sumatera Utara, 2019)Latar belakang: Identifikasi sel-sel basal dengan pewarnaan Hematoksilin dan Eosin (H&E) tidaklah mudah pada jaringan prostat. Sehingga bisa saja terjadi sel-sel basal mungkin tidak dikenali pada kelenjar-kelenjar jinak ... -
Analisa Faktor Dominan yang Berpengaruh pada Kejadian Malaria di Daerah Hypoendemis di Sumatera Utara : Pengembangan Model Prediksi Diagnosis Asymptomatic Malaria pada Layanan Kesehatan Prime
(Universitas Sumatera Utara, 2016)Background: Asymptomatic malaria is a source of new transmission of malaria infection. The inability to detect and handle, can fail the efforts of malaria elimination. Detection of asymptomatic malaria is usually done by ... -
Analisis Ekspresi Heat Shock Protein 70, Caspase 3 dan Komposisi Mikrobiota pada Penderita Kanker Kolorektal
(Universitas Sumatera Utara, 2016)Colorectal cancer is proven to be the fourth most cancer worldwide and as the second in United States. In Indonesia, from the several centre reports increase case per years This study was conducted as initial study to ... -
Analisis Peran Polimorfisme Gen CYP2R1 rs10741657, CYP27B1 rs10877012, Kadar Vitamin D pada Ibu Hamil Infeksi Laten Tuberkulosis terhadap Kadar Vitamin D, Katelisidin, Toll- Like Receptor 2, dan Interferon g pada Bayi Baru Lahir
(Universitas Sumatera Utara, 2023)Background. Latent Tuberculosis Infection (LTBI) in pregnant women can progress to active TB infection and potentially infect their newborns such that infection-mediated immune responses may affect the child's immune ... -
Analisis Polimorfisme Gen Adiponektin +45T/G dan +276G/T) dan Kadar Adiponektin Pasien dengan Aliran Lambat Pembuluh Darah Koroner pada Suku Aceh
(Universitas Sumatera Utara, 2019)Background: Until now, the etiology and mechanism of SCF have not been fully known. But looking at it through histopathology, microvascular inflammation has been found. APN is an important modulator of inflammation that ... -
Analisis Polimorfisme Gen Tumor Necrosis Factor- –308 G/A dan Kadar Tumor Necrosis Factor- Dengan Volume Otak pada Orang Dengan Skizofrenia
(Universitas Sumatera Utara, 2020)Background: There are three theories related to the etiology of schizophrenia, the first schizophrenia is a neurodevelopmental disease, second is a neurodegenerative disease, and third is a progressive neurodevelopment ... -
Derajat Kerusakan Ginjal Akibat Pelvic Ureteral Junction Obstruction Buatan terhadap Kadar NGAL, IL-18, dan Gambaran Histopatologis pada Tikus Wistar
(Universitas Sumatera Utara, 2023)Introduction Markers such as NGAL, and IL-8 have been associated with the degree of kidney injury that occurs due to an obstruction. This study aims to assess the degree of kidney injury due to pelvic ureteral junction ... -
Deteksi Rotavirus dan Karakterisasi Gen Nonstruktural NSP4 Rotavirus Sebagai Enterotoksin Virus yang Menginduksi Terjadinya Invaginasi pada Anak
(Universitas Sumatera Utara, 2015)Background Invagination is a disease in children which require emergency action. Factors associated with the occurrence of invagination during this time can not be determined exactly because 95% of the cause of invagination ... -
Efek Curcumin Terhadap Faktor Pengencer Darah, VAS, Kadar COX-2, IL-10, MDA, SOD, sFlt-1 dan VEGF pada Pasien Preeklampsia yang Menjalani Seksio Sesarea dengan Anestesi Spinal
(Universitas Sumatera Utara, 2020)Background: WHO states that preeclampsia is the second leading cause of maternal morbidity and mortality. Clinical symptoms of preeclampsia is hypertension, pain in the pit of the stomach and bleeding that may occur due ... -
Efek Diet Indeks Glikemik Rendah dengan Campuran Tempe Kedelai terhadap Konsentrasi Tissue - Type Plasminogen Activator (t-PA) Antigen, Plasminogen Activator Inhibitor Tipe-1 (PAI-1) Antigen dan Lipid Plasma Wanita Obesitas Dewasa
(Universitas Sumatera Utara, 2007)Prevalenve of obese is rapidly becoming one of the most important medical and public health problems in countries worldwide, as well as in Indonesia Epidemiological studies liave reported a progressive increases in ... -
Efek Ekstrak Buncis (Phaseolus Vulgaris L) terhadap Kadar Ldl dan Oxldl Serta Kaitannya dengan Polimorfisme Gen Lox-1 3’utr188c/T sebagai Upaya Preventif Risiko Aterosklerosis
(Universitas Sumatera Utara, 2014)Background: Atherosclerosis is an inflammatory disease that leads to the emergence of aterom plaque, which causes thickening of the blood vessel wall. Acute myocardial infarction (AMI) is caused by rupture of atherosclerotic ... -
Efek Ekstrak Daun Poguntano (Picria fel-terrae Merr.) Terhadap Kadar Protein Proinflamasi pada Tikus Galur Wistar Model Rinosinusitis Akut Bakterial
(Universitas Sumatera Utara, 2019)Acute bacterial rhinosinusitis (ABRS) is one of the most common inflammatory diseases to be investigated. Most acute rhinosinusitis generally of viral origin, only around 0.5-2% becomes acute bacterial rhinosinusitis. ... -
Efek Ekstrak Daun Semanggi Merah (Trifolium pratense) Terhadap Neurogenesis Serebral Melalui Modulasi Brain Derived Neurotrophic Factor dan Glial Cell Line-Derived Neurotrophic Factor Pada Tikus Galur Sprague-Dawley Model Penyakit Parkinson
(Universitas Sumatera Utara, 2025)Introduction: Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta caused by multifactorial factors. However, until now, the administration ... -
Efek Ekstrak Etanol dan Air Daun Belalai Gajah (Clinacanthus Nutans) terhadap Ekspresi Protein P53 Mouse Double Minute 2 Homolog dan AKt pada Sel Punca Kanker Payudara
(Universitas Sumatera Utara, 2024)Background: Breast cancer is the most common cancer among women in Indonesia with the number of new cases reaching 48,998. The advancement of medical technology in the implementation of cancer patients has not been able ... -
Efek Ekstrak Etanol Daun Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl) terhadap Kadar Glukosa Darah, Tumor Necrosis Factor-a, Interleukin-6 Serum serta Ekspresi Pospho-Amp Activated Protein Kinase Otot Skelet pada Tikus Model Diabetes
(Universitas Sumatera Utara, 2023)Background: Patients with diabetes mellitus experience hyperglycemia conditions that can activate pro-inflammatory cytokines such as TNF-α and IL-6, which play a role in the incidence of insulin resistance and the development ... -
Efek Ekstrak Ethanol Daun Binahong (Anredera cordifolia) sebagai Anti Obesitas terhadap Kadar ERK, PI3-K serta Ekspresi PPAR γ pada Tikus Putih Galur Wistar Model Obesitas
(Universitas Sumatera Utara, 2023)Background : Currently, obesity is a global health problem due to the high mortality rate of disease complications caused by obesity. Losing weight means reducing complications, by inhibiting the processes and pathways ... -
Efek Ekstrak Ikan Gabus (Channa striata) Terhadap Vascular Endothelial Growth Factor dan Nitric Oxide pada Angiogenesis Serebral Tikus Galur Sprague - Dawley Model Stroke Iskemik
(Universitas Sumatera Utara, 2020)Backgound: Changes in lifestyle due to modernization and globalization tend to increase the risk of vascular diseases such as coronary heart disease and stroke. Currently one of the ischemic stroke therapies is tissue ... -
Efek Latihan Isometrik Otot Plantar Fleksor Terhadap Aktivitas Osteoblast Diukur dengan Bone Specific Alkaline Phosphatase dan Pembentukan Kalus pada Pasien Post Open Reduction Internal Fixation Fraktur Tibia Non Articular
(Universitas Sumatera Utara, 2019)Background: Post operative non-articular tibia fracture several problems that can occur include; pain, muscles atrophy, muscles weakness, joint stiffness, delayed union, and non-union that makes patients limited in their ... -
Efek Pemberian Acth4-10pro8-Gly9-Pro10 terhadap Neurotoksisitas Ketamin Pada Rattus Novergicus Galur Sprague Dawley Postnatal Day-7 (Pnd-7) dengan Penilaian Ekspresi Caspase-3, Bcl-2, dan BDNF
(Universitas Sumatera Utara, 2022)Latar Belakang : Anestesi umum pada tindakan operasi biasa dilakukan kepada anak-anak di seluruh dunia. Penggunaan ketamin sudah terdokumentasi secara luas karena tingkat keamanan dan efikasi yang sangat baik untuk ...