Hubungan Rasio Platelet Limfosit pada Pasien Artritis Gout dengan Faktor Risiko Kardiovaskular di RSUP H. Adam Malik Medan

Abstract

The platelet-lymphocyte ratio (PLR) is a hematological marker that reflects the balance between platelets and lymphocytes, often used to assess inflammation and immune responses in various diseases. Elevated PLR has been associated with gouty arthritis, a condition characterized by monosodium urate crystal deposition due to chronic hyperuricemia. Gout is linked to cardiovascular risk factors like hypertension, obesity, dyslipidemia, and diabetes, contributing to systemic inflammation. This study aimed to examine the relationship between PLR and cardiovascular risk factors in gout patients at H. Adam Malik General Hospital. A cross-sectional analysis was conducted using secondary data from medical records of 67 gout patients diagnosed according to the 2015 American College of Rheumatology criteria. The mean PLR was 175.93, with 50.7% of patients categorized as having high PLR (≥136). A significant difference in PLR values was found between chronic and intercritical gout phases (p = 0.039). However, no significant correlation was observed between PLR and cardiovascular risk factors (p = 0.922). Dyslipidemia (p = 0.005) and smoking (p = 0.020) were significantly associated with PLR status. These findings suggest that while PLR may serve as an indicator of inflammation in gout, it does not directly correlate with cardiovascular risk factors. Further research with a larger sample size is needed to clarify the role of PLR in cardiovascular risk assessment in gout patients