Analisis Kadar Ureum Pre dan Post Hemodialisis pada Pasien Penyakit Ginjal Kronik di RS Prof. dr. Chairuddin P. Lubis Tahun 2024

Abstract

Background. Chronic kidney disease is a global health problem characterized by a progressive and irreversible decline in renal function. Hemodialysis is the main renal replacement therapy used to maintain biochemical balance in the body. One of the main indicators of hemodialysis adequacy is the reduction of blood urea levels. Aim. This study aimed to analyze the differences in blood urea levels before and after hemodialysis in patients with chronic kidney disease. Method. This was an analytical study using a retrospective cohort design based on medical records of 60 patients with chronic kidney disease undergoing regular hemodialysis at Prof. dr. Chairuddin P. Lubis Universitas Sumatera Utara Hospital, Universitas Sumatera Utara, Medan, 20155, INDONESIA in 2024. Samples were obtained using a simple random sampling technique. Data were analyzed using the paired sample t-test to compare pre and post hemodialysis urea levels. Results. The mean blood urea level before hemodialysis was 156.45 ± 33.94 mg/dL, which decreased to 41.81 ± 16.30 mg/dL after hemodialysis, with a mean urea reduction rate of 73.35 ± 8.87%. The paired sample t-test showed a p-value of 0.001 (p < 0.05), indicating a significant difference between urea levels before and after hemodialysis. Conclusion. There was a significant reduction in blood urea levels after hemodialysis, indicating that the hemodialysis procedure at Prof. Dr. Chairuddin P. Lubis Hospital, Medan, was effective in eliminating urea from patients with chronic kidney disease.