Doctoral Dissertations
Doctoral Dissertations
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Now showing items 21-40 of 177
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Pengaruh Fraksi Etil Asetat dari Ekstrak Bawang Dayak (Eleutherine bulbosa (Mill.) Urb) terhadap Sel Kanker Payudara T47D yang Dipaparkan Estrogen
(Universitas Sumatera Utara, 2024)Background: Breast cancer is the most common cause of cancer death in women and the fifth leading cause of all cancer deaths. In Indonesia, the high incidence of breast cancer is also accompanied by a low rate of treatment ... -
Efek Pemberian Isolat Oleuropein terhadap Kadar Apoptosis Inducing Factor, Glial Acidic Fibrillary Protein, Matrix Metalloproteinase-9 dan High Mobility Group Box-1 pada Tikus Model Cedera Otak Traumatik
(Universitas Sumatera Utara, 2023)Background : The incidence of head injuries in the world is currently touching 250 cases per 100,000 population worldwide. Two types of cell death can occur in head injury, namely necrosis and apoptosis. Polyphenols are ... -
Efek Ekstrak Ethanol Daun Binahong (Anredera cordifolia) sebagai Anti Obesitas terhadap Kadar ERK, PI3-K serta Ekspresi PPAR γ pada Tikus Putih Galur Wistar Model Obesitas
(Universitas Sumatera Utara, 2023)Background : Currently, obesity is a global health problem due to the high mortality rate of disease complications caused by obesity. Losing weight means reducing complications, by inhibiting the processes and pathways ... -
Pengaruh Sekretom Sel Punca Mesenkimal Hipoksia terhadap Percepatan Penyembuhan Luka Pasca Penempelan Split Thickness Skin Graft pada Model Luka Bakar Derajat Tiga
(Universitas Sumatera Utara, 2023)Background: Effective wound management is an important determinant of survival and prognosis of third-degree burn patients. Recently, autologous skin grafting techniques (skin grafts) such as split-thickness grafts (STSG) ... -
Pengaruh Tetes Mata Curcumin terhadap Penyembuhan Luka Laserasi Lamellar Kornea Ditinjau dari Penurunan Ekspresi IL-1, TNF-α, NFκB serta Perbaikan Gambaran Histopatologi Kornea Rattus Norvegicus
(Universitas Sumatera Utara, 2024)Backgroung Corneal lamellar lacerations are emergencies in ophthalmology that involve partial thickness of the cornea. Curcumin is a polyphenol derived from Rhizopus which has the ability to accelerate wound healing Purpose To ... -
Pengaruh Pemberian Ekstrak Etanol Jahe Merah (ZingibeR officinale Rosc. Var. RUBRUM) terhadap Kadar Interleukin 6 (IL-6), Interleukin 10 (IL-10) Tumor Necrotic Factor α (TNF- α) dan C-Reactive Protein (C-RP) pada Mencit (Mus musculus) Model Ansietas
(Universitas Sumatera Utara, 2023)Background: Anxiety disorders, with their psychological and physical symptoms, lead to a reduction in sufferers' quality of life and immunity. Moreover, their high prevalence globally, including in North Sumatra, has ... -
Hubungan Polimorfisme IL-1β-1903 C>T dan +3954 C>T dengan Kadar IL-1β terhadap Kejadian Anemia Defisiensi Besi pada Anak dengan Infeksi Helicobacter Pylori
(Universitas Sumatera Utara, 2023)Background: Helicobacter pylori (H. pylori) infection has long been known to cause iron deficiency anemia. However, the data above shows that not all children infected with H. pylori develop iron deficiency anemia. The ... -
Efek Pemberian Sekretom Sel Punca Mesenkimal terhadap Ekspresi NF-kB, Kadar TNF-α, IL-6, IL-10, IL-4 dan Ekspresi PD-1, PD-L1 serta Survival Rate Tikus Model Sepsis
(Universitas Sumatera Utara, 2023)Introduction: Currently worldwide, the mortality rate due to sepsis is still high. The uncontrolled inflammatory response with the imbalance of pro-inflammatory and anti-inflammatory as well as the increased release of ... -
Efek Ekstrak Etanol Daun Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl) terhadap Kadar Glukosa Darah, Tumor Necrosis Factor-a, Interleukin-6 Serum serta Ekspresi Pospho-Amp Activated Protein Kinase Otot Skelet pada Tikus Model Diabetes
(Universitas Sumatera Utara, 2023)Background: Patients with diabetes mellitus experience hyperglycemia conditions that can activate pro-inflammatory cytokines such as TNF-α and IL-6, which play a role in the incidence of insulin resistance and the development ... -
Efek Ekstrak Etanol Daun Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl) terhadap Kadar Glukosa Darah, Tumor Necrosis Factor-Α, Interleukin-6 Serum serta Ekspresi Pospho-AMP Activated Protein Kinase Otot Skelet pada Tikus Model Diabetes
(Universitas Sumatera Utara, 2023)Background: Patients with diabetes mellitus experience hyperglycemia conditions that can activate pro-inflammatory cytokines such as TNF-α and IL-6, which play a role in the incidence of insulin resistance and the development ... -
Analisis Peran Polimorfisme Gen CYP2R1 rs10741657, CYP27B1 rs10877012, Kadar Vitamin D pada Ibu Hamil Infeksi Laten Tuberkulosis terhadap Kadar Vitamin D, Katelisidin, Toll- Like Receptor 2, dan Interferon g pada Bayi Baru Lahir
(Universitas Sumatera Utara, 2023)Background. Latent Tuberculosis Infection (LTBI) in pregnant women can progress to active TB infection and potentially infect their newborns such that infection-mediated immune responses may affect the child's immune ... -
Pengaruh Pemberian Ekstrak Bawang Putih (Allium sativum L.), Ekstrak Daun Mint (Mentha piperita L.), dan Kombinasi Keduanya terhadap Ekspresi Gen SFTP-A1, Kadar Glutation, dan Makrofag Alveolar Tikus Model Perokok
(Universitas Sumatera Utara, 2023)Background. Exposure to secondhand smoke is the leading cause of death worldwide and is known as a risk factor in the development and pathogenesis of several diseases, most of which are respiratory and cardiovascular ... -
Pengaruh Intra-Arterial Heparin Flushing terhadap Hasil Audiometri Nada Murni, Distortion Product Otoacoustic Emission, Kadar Prestin, dan Kadar Vascular Endothelial Growth Factor pada Pasien dengan Gangguan Pendengaran di RSPAD Gatot Subroto
(Universitas Sumatera Utara, 2023)Background: Several causes of sensorineural hearing loss are known to cause cochlear vascular changes such as changes in blood flow, increased vascular permeability, and vasoconstriction. The sensorineural type hearing ... -
Pengaruh Pemberian Sekretom Sel Punca Mesenchymal Hipoksia terhadap Ekspresi Gen Vascular Endothelial Derived Growth Factor (VEGF), Platelet Derived Growth Factor (PDGF), Thrombospondin-4 (TSP-4) dan Angiogenesis pada Tikus Model Diabetes Mellitus dengan Hindlimb Ischemia
(Universitas Sumatera Utara, 2023)Introduction: Diabetes is a major health problem in the world where one of the complications is Peripheral Arterial Disease (PAD). Mesenchymal stem cells are reported to have several growth factors that play a role in ... -
Pengaruh Continuous Training Intensitas sedang dan Interval Training Tipe Lambat terhadap Ekspresi Gen TLR-4, TGF-β dan Sel Mononuclear Ginjal Tikus Wistar Model Diabetes Melitus Tipe-2
(Universitas Sumatera Utara, 2023)Background: Physical exercise is a process of increasing contraction of skeletal muscles involving several organ systems to increase energy formation and it is one of the pillars for the management of type 2 diabetes ... -
Derajat Kerusakan Ginjal Akibat Pelvic Ureteral Junction Obstruction Buatan terhadap Kadar NGAL, IL-18, dan Gambaran Histopatologis pada Tikus Wistar
(Universitas Sumatera Utara, 2023)Introduction Markers such as NGAL, and IL-8 have been associated with the degree of kidney injury that occurs due to an obstruction. This study aims to assess the degree of kidney injury due to pelvic ureteral junction ... -
Pengaruh Ekstrak Etanol Daun Puguntano (Curanga felterrae (Lour) Merr.) terhadap Ekspresi Tgf-B1, E-Selectin, Glomerulosklerosis, Fibrosis Interstisial, dan Fungsi Ginjal pada Tikus Galur Wistar yang Diberi Doxorubicin
(Universitas Sumatera Utara, 2023)Background: The use of Doxorubicin (DXR) in the treatment of cancer is increasing, with increasing cancer morbidity. The nephrotoxic effect of DXR is still a problem. Puguntano leaf ethanol extract as an anti-inflammatory ... -
Pengaruh Pemberian Ekstrak Buah Andaliman (Zanthoxylum acanthopodium Dc) terhadap Kultur Sel Melanoma B16F10
(Universitas Sumatera Utara, 2023)Background: Melanoma is a type of skin cancer with increasing prevalence and a poor prognosis when lesions penetrate to dermis. Melanoma cells exhibit high proliferation rates and low responsiveness to available chemotherapy ... -
Hubungan HSP 70 dengan p53, Cytochrome C, Caspase 3 dan Kerusakan Koklea Melalui Heat Shock Respon Akibat Paparan Bising
(Universitas Sumatera Utara, 2015)Background. Noise is one of the factors of stress and often disturbing around our neighborhood. Exposure to high noise more than 85 dB and continuously can cause permanent damage Organ of Corti and the auditory nerve. The ... -
Efek Diet Indeks Glikemik Rendah dengan Campuran Tempe Kedelai terhadap Konsentrasi Tissue - Type Plasminogen Activator (t-PA) Antigen, Plasminogen Activator Inhibitor Tipe-1 (PAI-1) Antigen dan Lipid Plasma Wanita Obesitas Dewasa
(Universitas Sumatera Utara, 2007)Prevalenve of obese is rapidly becoming one of the most important medical and public health problems in countries worldwide, as well as in Indonesia Epidemiological studies liave reported a progressive increases in ...
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