| dc.description.abstract | Background: Formalin exposure is known to cause oxidative stress and tissue damage,
including nephrotoxicity. The kidney is a major organ affected by formalin toxicity due to
its role in filtration and metabolic detoxification. Objective: This study aimed to evaluate
the effect of kidney histopathology, body and kidney weight induced of different
concentration inhaled formalin in rats (Rattus norvegicus). Methods: This true
experimental study employed a post-test only control group design, consisting of four
groups (n = 6 per group): control (K0), formalin 10 ppm (K1), formalin 50 ppm (K2),
and formalin 100 ppm (K3). Formalin exposure was administered via inhalation for four
weeks. Body weight, kidney weight, and histopathological score were evaluated. Tubular
and glomerular damages were analyzed with Kruskal-Wallis test followed by post hoc
Mann-Whitney test, body weight before and after experimentalwith paired t-test, kidney
weight with One-Way ANOVA test. Results: Formalin exposure induced significant
decreased in both body weight K3 100ppm (p=0.031) and kidney weight K2 50ppm
(p=0.001) compared the control group . The Kruskal–Wallis test showed a significant
difference in tubular injury among groups (p < 0.05), with more severe damage observed
in the K2 50ppm and 100ppm groups (p= 0.010; p= 0.041). However, glomerular scores
showed no significant difference among groups (p = 0.07). Conclusion: Inhalation of
formalin, particularly at concentrations of 50–100ppm, induced kidney damage
characterized by tubular necrosis and reduction in kidney weight. These findings suggest
that prolonged or repeated exposure to formalin may contribute to oxidative stress
mediated renal structural deterioration and functional impairment. | en_US |
