Penyembuhan Luka Pencabutan Gigi Tikus Hipoalbuminemia Setelah Pemberian Protein Gummy Intra-Socket Berbahan Albumin, Nanokolagen, Gelatin Ayam Konsentrasi 25:10:30 dan 35:15:30

Abstract

Hypoalbuminemia is body condition where there is a lack of albumin levels in the blood, characterized by albumin levels <3.5 g/dL. Hypoalbuminemia can prolog wound healing time, necessitating additional albumin from food or supplements. Albumin can be obtained from free-range chicken eggs. Collagen also accelerating wound healing and can be obtained from broiler chicken leg bones. The aim of this research is to analyze the optimal formulation of intra-socket protein gummy made from albumin, nanocollagen, and gelatin at concentrations of 25:10:30 and 35:15:30 on the healing time of tooth extraction wounds and the formation of fibroblast cells in rats models of hypoalbuminemia. Albumin is extracted from chicken eggs using the dialysis method, while nanocollagen and gelatin are extracted from broiler chicken feet using the soaking method. This research used 24 Gallur Wistar rats (Rattus norvegicus) which were fed a low protein diet for 14 days. Wound healing time was measured by assessing signs of inflammation which were observed every 2 days for 14 days and measuring the number of fibroblasts using histopathological examination. The mean results and standard deviation of wound healing time for groups I, II, and III were 13 ± 2.44 days, 6±0 days, and 8.67 ± 3.26. Based on histopathological interpretation, the mean and standard deviation of the number of fibroblast cells for groups I, II, and III were 7.17 ± 9.86, 22.33 ± 13.15, and 13.67 ± 12,5. It can be concluded that intra-socket protein gummy (25%:10%:30%) can accelerate wound healing after tooth extraction in hypoalbuminemia model rats.