Hubungan Tingkat Keparahan Depresi Dengan Dislipidemia Pada Pasien Neuropati Diabetik

Abstract

Diabetic neuropathy is one of the most common complications of type 2 diabetes mellitus and is associated with an increased risk of depression. Depression may contribute to dyslipidemia through mechanisms involving chronic inflammation, hypothalamic–pituitary–adrenal axis activation, and lifestyle or metabolic alterations. However, the relationship between the severity of depression and lipid abnormalities in patients with diabetic neuropathy remains inconsistent across studies. This study aimed to evaluate the association between depression severity and dyslipidemia in patients with diabetic neuropathy at H. Adam Malik General Hospital. This analytic cross-sectional study was conducted from September to October 2025 and included 45 patients aged ≥18 years with diabetic neuropathy. Depression severity was assessed using the Beck Depression Inventory (BDI), whereas dyslipidemia was determined based on a complete lipid profile. Statistical analysis was performed using Fisher’s Exact test, with p<0.05 considered significant. The results showed no significant association between the severity of depression and the overall incidence of dyslipidemia. There was no significant relationship between depression severity and triglyceride levels (p=0.259), LDL cholesterol (p=0.727), or total cholesterol (p=0.507). However, a significant association was found between the severity of depression and HDL cholesterol levels (p=0.001). In conclusion, the severity of depression is not associated with dyslipidemia overall in patients with diabetic neuropathy, but it is significantly associated with reduced HDL cholesterol levels. Keywords: Depression, Diabetic Neuropathy, Dyslipidemia, Beck Depression Inventory (BDI)