| dc.description.abstract | Diabetic neuropathy is one of the most common complications of type 2 diabetes
mellitus and is associated with an increased risk of depression. Depression may
contribute to dyslipidemia through mechanisms involving chronic inflammation,
hypothalamic–pituitary–adrenal axis activation, and lifestyle or metabolic
alterations. However, the relationship between the severity of depression and lipid
abnormalities in patients with diabetic neuropathy remains inconsistent across
studies. This study aimed to evaluate the association between depression severity
and dyslipidemia in patients with diabetic neuropathy at H. Adam Malik General
Hospital. This analytic cross-sectional study was conducted from September to
October 2025 and included 45 patients aged ≥18 years with diabetic neuropathy.
Depression severity was assessed using the Beck Depression Inventory (BDI),
whereas dyslipidemia was determined based on a complete lipid profile. Statistical
analysis was performed using Fisher’s Exact test, with p<0.05 considered
significant. The results showed no significant association between the severity of
depression and the overall incidence of dyslipidemia. There was no significant
relationship between depression severity and triglyceride levels (p=0.259), LDL
cholesterol (p=0.727), or total cholesterol (p=0.507). However, a significant
association was found between the severity of depression and HDL cholesterol
levels (p=0.001). In conclusion, the severity of depression is not associated with
dyslipidemia overall in patients with diabetic neuropathy, but it is significantly
associated with reduced HDL cholesterol levels.
Keywords: Depression, Diabetic Neuropathy, Dyslipidemia, Beck Depression
Inventory (BDI) | en_US |
