Hubungan Kadar Cathelicidin terhadap Kualitas Hidup Pasien Prolapse Menggunakan P-Qol (Prolapse Quality of Life Questionnaire) dan Derajat III - IV Prolaps Organ Panggul di RS Prof. Dr. Chairuddin P. Lubis Universitas Sumatera Utara Medan dan RSUD Pirngadi Medan

Abstract

Background: Pelvic organ prolapse (POP) is a common pelvic floor disorder in older women and significantly affects quality of life. The severity of POP is thought to be associated with alterations in the pelvic tissue microenvironment, including inflammatory processes and innate immune responses. Cathelicidin is an antimicrobial peptide with a key role in immune modulation and inflammation; however, its relationship with quality of life and POP severity remains poorly understood. Objective: To evaluate the association between cathelicidin levels and quality of life assessed using the Prolapse Quality of Life Questionnaire (P-QoL), as well as the severity of stage III–IV pelvic organ prolapse. Methods: This observational analytic study used a cross-sectional design and was conducted at Prof. Dr. Chairuddin P. Lubis Hospital, Universitas Sumatera Utara, and Pirngadi General Hospital, Medan. The study included women aged ≥40 years diagnosed with stage III–IV POP based on the POP-Q system. Serum cathelicidin levels were measured, quality of life was assessed using the P-QoL questionnaire, and POP severity was determined through clinical examination. Statistical analyses were performed to assess the associations between cathelicidin levels, quality of life, and prolapse severity. Results: A significant association was found between cathelicidin levels and quality of life in patients with POP, with lower cathelicidin levels associated with poorer P-QoL scores. Additionally, decreased cathelicidin levels were significantly associated with more severe prolapse stages. Conclusion: Cathelicidin levels are associated with both quality of life and the severity of pelvic organ prolapse. Cathelicidin may serve as a potential biomarker reflecting inflammatory and immune processes in advanced POP and could be considered in the clinical evaluation of affected patients.