| dc.description.abstract | Background: Sepsis is the most common cause of Acute Kidney Injury (AKI).
Diagnosis of AKI based on serum creatinine (sCr) has limitations, sCr increases
only after >50% kidney function is lost. uACR examination is a simple test to
assess microalbuminuria which reflects impaired kidney function.
Objective: Analyzing the correlation between uACR and AKI incidence in sepsis
patients treated at Adam Malik Hospital.
Methods: The study design was observational analytic with prospective cohort
design. Samples were taken consecutively. Sepsis diagnosis was based on qSOFA
score. uACR and sCr I were checked <24 hours after sepsis was diagnosed, sCr II
was rechecked 48 hours later to assess the occurrence of AKI. Data were analyzed
using SPSS.
Results: There were 52 study subjects, predominantly male (57,7%), with an
average age of 52,5±16,42 years, and the most common source of infection was
the lungs (82,7%). AKI occurred in 46,2% of study subjects. The AUC area of
uACR as a predictor of AKI was 75,2%. The independent variable that
significantly influenced AKI was uACR (p<0,001). The uACR cut-off was 225
mg/g, with a sensitivity of 83,3%, a specificity of 67,9% and an accuracy rate of
75%. uACR levels ≥225 mg/g had a 10,556 times risk of AKI.
Conclusion: There is a significant correlation between uACR and the incidence of
AKI so it can be used as a predictor of AKI in sepsis patients. | en_US |
