Hubungan Nilai Systemic Inflammation Response Index (SIRI) dengan Perubahan Nilai Kreatinin Pada Pasien Penyakit Ginjal Kronik (PGK) Non Hemodialisis di RS Adam Malik

Abstract

Objective : To determine the association between Systemic Inflammation Response Index (SIRI) values and changes in creatinine levels in non-hemodialysis Chronic Kidney Disease (CKD) patients at Adam Malik Hospital.

Methods : This is an observational analytical study with a prospective cohort design to determine the association between Systemic Inflammation Response Index (SIRI) values and changes in creatinine levels in non-hemodialysis Chronic Kidney Disease (CKD) patients at Adam Malik Hospital. Sample collection was conducted using consecutive sampling techniques, considering inclusion and exclusion criteria. Descriptive statistical analysis was used for demographic data. Chi-square analysis was performed to analyze the relationship between variable categories. The research data were statistically analyzed using SPSS, and differences were considered significant if p<0.05.

Results : From the 49 sample, the median age was 58 (22–27) years, with a slightly higher male population than female (55.1% vs. 44.9%). The most common comorbidity in this study was hypertension, with 34 patients (69.4%), and the most common stage of CKD was stage II, with 12 patients (24.5%). The mean absolute monocyte count was 0.77 ± 0.41 x 103/µl, the mean absolute lymphocyte count was 1.59 ± 0.59 x 103/µl, and the median absolute neutrophil count was 6.97 (1.30–78.87) x 103/µl. 4. The median Systemic Inflammation Response Index (SIRI) values was 3.32 (0.24 – 75.5), with 5 patients having normal SIRI scores (10.2%) and 44 patients having high SIRI scores (89.8%).

Conclusion : No significant association was found between SIRI values and changes in creatinine levels in non-hemodialysis chronic kidney disease (CKD) patients at Adam Malik Hospital (p=0.143).