Efektvitas Penggunaan Film Kitosan Cangkang Kepiting Hitam (Scylla serrata) terhadap Penyembuhan Luka Gores pada Mukosa Rongga Mulut Tikus Galur Wistar (Rattus norvegicus)

Abstract

Chitosan is a natural biopolymer that is biocompatible and biodegradable, and it has potential anti-inflammatory and antimicrobial properties, making it a promising accelerator of wound healing. This study aimed to evaluate the effectiveness of chitosan film derived from the shells of giant mud crab (Scylla serrata) at concentrations of 1%, 2%, and 3% on the healing of buccal mucosal scratch wound in Wistar rats, based on the parameters of erythema and wound-length closure. This was an experimental study with five treatment groups. Scratch wound were created on the buccal mucosa, and the treatments were applied twice daily for seven days. Erythema and wound-length closure were assessed on days 1, 3, and 7. The data were analyzed using Pearson Chi-square test for erythema, and the Kruskal–Wallis and Mann–Whitney tests for wound-length closure. The results showed that giant mud crab shell chitosan film was effective in promoting the healing of buccal mucosal scratch wound in Wistar rats.