Efektivitas Nanoemulgel Minyak Sawit Merah (Elaeis guineensis Jacq.) Konsentrasi 2% Terhadap Jumlah Sel Fibroblas Pasca Pencabutan Gigi Tikus Galur Wistar (Rattus norvegicus)

Abstract

Following tooth extraction, wound healing physiologically occurs, which systematically consists of several phases, hemostasis, inflammation, proliferation, and remodeling. Fibroblasts play an important role in the proliferation phase, especially in the formation of new extracellular matrix needed to restore the structure and function of damaged tissue. Fibroblast activity continues until the remodeling phase, during which the produced collagen undergoes maturation and reorganization to form stronger and more stable tissue. Natural ingredients that can be used to speed up wound healing is red palm oil (Elaeis guineensis Jacq.). The healing properties of red palm oil have been reported in several studies, but there has been no research related to wound healing after tooth extraction. This study aims to analyze the effect of red palm oil nanoemulgel on fibroblast proliferation in wound healing after tooth extraction in Wistar rat strains. This study is an experimental laboratory research using 9 treatment groups that will be observed until the 3rd, 5th, and 7th days. The results of the study were measured by calculating the Mean Cell Count of fibroblasts. Data analyzed using one way ANOVA and post-hoc tests showed a significant difference in the mean number of fibroblast cells (p<0.05). Observations showed that red palm oil nanoemulgel is effective in fibroblast proliferation in wound healing post-tooth extraction.