Hubungan Kadar Asam Urat dengan Kejadian Ketuban Pecah Dini di RS Adam Malik dan Rumah Sakit Jejaring

Abstract

Background: Premature rupture of membranes (PROM) is an obstetric complication that contributes to maternal and perinatal morbidity. Uric acid has a dual role as an antioxidant; however, at higher levels it may promote inflammation. Therefore, alterations in maternal uric acid levels are presumed to be associated with oxidative stress processes and increased vulnerability of the fetal membranes. This study aimed to determine the association between serum uric acid levels and the incidence of PROM at Adam Malik Hospital and affiliated network hospitals. Methods: This analytical cross-sectional study was conducted at Adam Malik Hospital and network hospitals (Prof. dr. CPL USU Hospital and Pirngadi General Hospital, Medan) from March to July 2025. Participants were divided into two groups: pregnant women with PROM and pregnant women without PROM, with 25 subjects in each group (total n = 50). Results: Data were analyzed using univariate and bivariate methods with statistical tests selected according to data distribution. Most respondents were aged 20–30 years (66%); the most common body mass index (BMI) category was overweight (64%), and parity was predominantly primigravida (56%). The PROM group had a higher BMI (median 29.2 kg/m²) than the non-PROM group (median 27.5 kg/m²; p = 0.001), and BMI category was significantly associated with PROM (p = 0.034). Serum uric acid levels were lower in the PROM group (median 3.7 mg/dL) than in the non-PROM group (median 5.4 mg/dL; p = 0.001). There was a significant association between serum uric acid levels and PROM (p = 0.008). Conclusion: Serum uric acid levels were significantly associated with the incidence of PROM among pregnant women at Adam Malik Hospital and affiliated network hospitals.