Kadar Vitamin D dalam Darah Penderita Multidrug Resistent Tuberculosis di RSUP Haji Adam Malik Medan

Abstract

Latar belakang: Pemberantasan Tuberculosis (TB) menjadi bertambah berat sejak munculnya strain Mycobacterium tuberculosis (M. tuberculosis) yang resisten terhadap obat. Data surveilans resistensi obat menunjukkan bahwa diperkirakan terdapat 480.000 orang penderita MDR-TB dan 210.000 orang meninggal. Vitamin D sering dihubungkan dengan kejadian MDR-TB. Sementara penelitian vitamin D dan MDR-TB di Indonesia masih sangat jarang. Tujuan dari penelitian ini adalah untuk mengetahui kadar vitamin D penderita MDR-TB di RSUP Haji Adam Malik Medan. Metode Penelitian: Penelitian ini menggunakan metode deskriptif dengan cara mengukur kadar vitamin D penderita MDR-TB. Hasil: Semua penderita MDR TB termasuk kriteria resistensi sekunder. Penderita MDR TB terbanyak adalah penderita dengan riwayat OAT kategori 1 putus berobat (40%), diikuti dengan penderita dengan riwayat OAT kategori 2 putus berobat (33%). Kadar vitamin D rata-rata pada MDR TB adalah dibawah normal yaitu 29.01 mg/dl. Kesimpulan : Kadar vitamin D di dalam serum penderita MDR-TB adalah dibawah normal.

Background: Eradication of Tuberculosis (TB) becomes increasingly severe since the emergence of strains of Mycobacterium tuberculosis (M. tuberculosis) that are resistant to drugs. Drug resistance surveillance data shows that there are an estimated 480,000 MDR-TB sufferers and 210,000 people die. Vitamin D is often associated with MDR-TB events. While research on vitamin D and MDR-TB in Indonesia is still very rare. The purpose of this study was to determine the vitamin D levels of MDR-TB patients in Haji Adam Malik Hospital Medan. Methods: This study used a descriptive method by measuring vitamin D levels of MDR-TB patients Results: All MDR TB patients are included in the criteria for secondary resistance. Most MDR TB sufferers were patients with a history of OAT category 1 discontinued treatment (40%), followed by patients with a history of OAT category 2 dropped out of treatment (33%). The average vitamin D level in MDR TB is below normal, which is 29.01 mg / dl. Conclusion: Vitamin D levels in the serum of MDR-TB patients are below normal.