Korelasi Leukotrien Terhadap Densitas Massa Tulang pada Wanita Menopause

Abstract

Penelitian ini merupakan penelitian deskriptif dengan pendekatan case Untuk mengetahui korelasi nilai leukotrien dengan densitas tulang pada wanita menopause. Penelitian ini dilakukan di SMF Obstetri dan Ginekologi RSUP H. Adam Mlaik- Departemen obstetri dan ginekologi FK USU dilakanakan Desember 2018 sampai Februari 2019. Sampel yang memenuhi kriteria inklusi dan eksklusi kemudian diambil darahnya dan diperiksa kadar Leukotrien serum kemudian dilakukan pemeriksaan Bone Mass Density (BMD). Lalu dilakukan analisa korelasi secara statistik untuk menilai hubungan kadar leukotrien dan Bone Mass Density wanita Menopause. Dari hasil penelitian, Sebagian besar subjek penelitian tergolong dalam klasifikasi osteopenia yaitu sebanyak 23 orang (76.7%), pada penelitian ini juga terdapat 2 (6.7%) subjek yang mengalami osteoporosis dan sisanya dalam keadaan normal sebanyak 5 orang (16.7%). Penelitian ini menyimpulkan adanya korelasi yang signifikan antara kadar leukotrien dengan densitas massa tulang (r = - 0,533; p = 0.020) dengan korelasi dengan r hitung untuk densitas massa tulang lebih besar dari r tabel dan bernilai negatif.

This research is a descriptive study with a case approach to determine the correlation of the value of leukotrien with bone density in menopausal women. This research was carried out at Obstetrics and Gynecology SMF at H. Adam Malik General Hospital. The USU Department of Obstetrics and Gynecology was conducted in December 2018 until February 2019. Samples that met the inclusion and exclusion criteria were then drawn for blood and examined for serum leukotrien levels and Bone Mass Density (BMD) examination. Then a statistical correlation analysis was performed to assess the relationship between levels of leukotrien and Bone Mass Density for Menopause women. From the results of the study, most of the research subjects belong to the classification of osteopenia as many as 23 people (76.7%), in this study there were also 2 (6.7%) subjects who had osteoporosis and the rest in normal conditions as many as 5 people (16.7%). This study concludes that there is a significant correlation between leukotrien levels and bone mass density (r = - 0,533; p = 0.020) with a negative correlation with r count for bone mass density greater than r table.