Korelasi Kadar Estradiol dengan Kadar Monocyte Chemotactic Protein-1 (MCP-1) pada Urin Wanita Menopause dengan Overactive Bladder

Abstract

Latar Belakang: Peningkatan risiko terjadinya overactive bladder pada wanita menopause dan terdapat bukti dari penelitian terdahulu tentang pengaruh penurunan estradiol memainkan peran dalam terjadinya peningkatan mediator inflamasi dan menyebabkan tingginya kadar MCP-1 pada individu yang mengalami overactive bladder, maka peneliti tertarik untuk meneliti korelasi antara kadar Estradiol dalam darah sebagai penanda resiko terjadinya inflamasi dengan kadar MCP-1 pada urin wanita menopause dengan overactive bladder di RSUP H Adam Malik Medan. Tujuan: Menilai korelasi antara kadar Estradiol dengan kadar Monocyte Chemotactic Protein- 1 (MCP-1) urin pada pasien menopause dengan Overactive bladder di RSUP H Adam Malik Medan. Metode: Penelitian ini merupakan penelitian analitik observasional dengan desain penelitian case series untuk menilai korelasi antara kadar Estradiol dengan Monocyte Chemotactic Protein-1 (MCP-1) urin pada wanita menopause yang dengan overactive bladder. Sampel adalah seluruh paramedis wanita yang sudah menopause dengan overactive bladder di RSUP H Adam Malik Medan yang memenuhi kriteria inklusi dan eksklusi menggunakan metode non probability dengan teknik consecutive sampling. Semua data dikumpulkan kemudian dianalisa. Data dianalisis menggunakan uji korelasi Pearson bila data tidak berdistribusi normal dan uji Speramen bila data berdistribusi tidak normal. Nilai p kurang dari 0,05 dianggap signifikan dengan CI 95%. Hasil: Dari hasil penelitian didapatkan karakteristik pasien OAB. primipara, sekundipara dan multipara masing-masing 1 (2,9%), sekundipara 13 (38,2%) dan 20 (58,8%). Berdasarkan normoweight dan overweight sebanyak 6 (17,6%) dan 28 (82,4%), lama menopause, 2-3 tahun, 4 tahun, dan 5 tahun masing-masing 20 (58,8%), 12 (35,3%), dan 2 (5,9%), usia, 40-49 tahun 24,26 ±5,73 (154-37,8). nilai MCP 1 urin berdasarkan score OABSS ringan, sedang, berat masing-masing 92,81 ± 4,44; 108,53 ± 10,21; 156 ± 10,21; uji korelasi spearmen didapatkan Protein-1 (MCP-1) urin pada wanita menopause dengan overactive bladder didapatkan nilai r -0.658 Kesimpulan:terdapat korelasi negatif antara kadar Estradiol dengan Monocyte Chemotactic Protein-1 (MCP-1) urin pada wanita menopause dengan overactive bladder

Background: The increased risk of overactive bladder in postmenopausal women and there is evidence from previous studies about the effect of decreasing estradiol playing a role in increasing inflammatory mediators and causing high levels of MCP-1 in individuals who experience overactive bladder, the researchers were interested in examining the correlation between levels Estradiol in the blood is a marker of the risk of inflammation with levels of MCP-1 in the urine of menopausal women with overactive bladder at RSUP H Adam Malik Medan. Objective: Assessing the correlation between Estradiol levels and urine levels of Monocyte Chemotactic Protein-1 (MCP-1) in menopausal patients with Overactive Bladder at H Adam Malik General Hospital Medan. Method:This study was an observational analytic study with a case series research design to assess the correlation between Estradiol levels and urine urine Monocyte Chemotactic Protein- 1 (MCP-1) in postmenopausal women with overactive bladder. The sample was all menopausal female paramedics with overactive bladder at H Adam Malik General Hospital Medan who met the inclusion and exclusion criteria using non-probability methods with consecutive sampling technique. All data collected is then analyzed. Data were analyzed using the Pearson correlation test if the data were not normally distributed and the Speramen test if the data were not normally distributed. A p value of less than 0.05 was considered significant with 95% CI. Results:From the results of the study found the characteristics of OAB patients. primipara, sekundipara and multipara 1 (2.9%), sekundipara 13 (38.2%) and 20 (58.8%). Based on normoweight and overweight as many as 6 (17.6%) and 28 (82.4%), menopause, 2-3 years, 4 years, and 5 years respectively 20 (58.8%), 12 (35, 3%), and 2 (5.9%), age, 40-49 years and 50 - 59 years, respectively 2 (5.9%) and 32 (94.1%). the value of urinary estradiol was based on a spearmen correlation test found a very strong negative correlation correlation coefficient - 24.26 ± 5.73 (154-37.8). urine MCP 1 value based on a mild, moderate OABSS score of 92.81 ± 4.44; 108.53 ± 10.21; 156 ± 10.21; Spearmen correlation test obtained a correlation coefficient value of 0.856; p <0.001. Estradiol correlation with urine Monocyte Chemotactic Protein-1 (MCP-1) in postmenopausal women with overactive bladder r value -0.658 Conclusion:there is a negative correlation between Estradiol levels and urine urine Monocyte Chemotactic Protein-1 (MCP-1) in menopausal women with overactive bladder