Hubungan Kadar Estradiol dengan Keluhan Menopause Berdasarkan Menopause Quality of Life pada Pasien Kanker Serviks Pasca Radiasi Komplit

Abstract

Tujuan: Mengetahui hubungan kadar estrogen serum dengan keluhan menopause berdasarkan Menopause Quality Of Life (MENQOL) pada pasien kanker serviks pasca radiasi komplit. Metode: Penelitian ini merupakan suatu penelitian analitik korelatif dengan desain cross sectional. Subjek penelitian sebanyak 52 wanita menopause yang menderita kanker serviks dan telah mendapat radiasi komplit di RS H.Adam Malik Medan mulai Desember 2018 sampai jumlah sampel terpenuhi. Subjek diseleksi dengan consecutive sampling. Sampel darah diambil untuk dilakukan pemeriksaan kadar estradiol kemudian dibandingkan dengan survey Menopause Quality of Life (MENQOL). Data dianalisis menggunakan statististik uji t-test independent dan uji korelasi Pearson. Nilai p kurang dari 0,05 diterapkan pada setiap uji statistik sebagai signifikan. Hasil: Dari subjek penelitian 52 orang. mayoritas subjek penelitian berasal dari kelompok usia 35-45 tahun dengan 37 subjek (71.2%), multipara dengan 41 subjek (78,8%), BMI normoweight dengan 31 subjek (59,6%), lama menopause selama 7-9 bulan dengan 20 subjek (38.5%) dan periode pasca sinar memasuki masa 1 tahun dengan 37 subjek (71.2%). Berdasarkan stadium kanker serviks dijumpai subjek terbanyak pada stadium IIB sebanyak 33 subjek (63,5%). Berdasarkan stadium kanker serviks dijumpai subjek terbanyak pada stadium IIB sebanyak 33 subjek (63,5%). Berdasarkan hubungan kadar estradiol dengan keluhan Menopause Bedasarkan Menopause Quality Of Life (MENQOL ) pada pasien kanker serviks yang telah mendapatkan radiasi komplit didapatkan hubungan dengan kekuatan sedang sebesar 0.297 pada aspek psikomotor dan 0.323 pada aspek gangguan fisik dengan nilai P 0.032 dan P 0.019 Kesimpulan: Terdapat hubungan kadar estradiol dengan keluhan Menopause Bedasarkan Menopause Quality Of Life (MENQOL) pada pasien kanker serviks yang telah mendapatkan radiasi komplit

Objective: Knowing the relationship of serum estrogen levels with menopause based on Menopause Quality of Life (MENQOL) in patients with complete post-radiation cervical cancer. Method: This research is correlation analytic research with cross sectional design. The subjects of the study were 52 menopausal women who had cervical cancer and received complete radiation in H. Adam Malik Hospital Medan from December 2018 to the number of samples fulfilled. Subjects were selected by consecutive sampling. Blood samples were taken for examination of estradiol levels and then compared with Menopause Quality of Life (MENQOL) survey. Data were analyzed using independent t-test statistical tests and Pearson trials. A p value of less than 0.05 was applied to each statistical test as significant. Results: From the research subjects 52 people. With 35-45 years of study subjects with 37 subjects (71.2%), multiparous with 41 subjects (78.8%), normoweight BMI with 31 subjects (59.6%), menopause for 7-9 months with 20 subjects (38.5%) and the period after sunlight entered the 1 year period with 37 subjects (71.2%). Based on the stage of cervical cancer found the most subjects in stage IIB as many as 33 subjects (63.5%). Based on the stage of cervical cancer found the most subjects in stage IIB as many as 33 subjects (63.5%). Based on the relationship between estradiol levels and balance of Menopause Based on Menopause Quality of Life (MENQOL) in cervical cancer patients who have received complete radiation obtained a relationship with greater strength of 0.297 on the psychomotor aspect and 0.323 on the security aspect with a P value of 0.032 and P 0.019 Conclusion: There is a correlation between estradiol levels and complaints of Menopause Based on Menopause Quality of Life (MENQOL) in cervical cancer patients who have received complete radiation