Klinikohistopatologi Pasien Kanker Serviks dengan Respon Radiasi

Abstract

Latar belakang: Kanker serviks adalah salah satu kanker yang menempati urutan keempat yang paling banyak diderita wanita di dunia. Dengan insidensi tertinggi di Amerika bagian Tengah dan Selatan, Afrika bagian sub-Sahara dan Asia. Biasanya pasien datang pada stadium lanjut. Prognosis penderita kanker serviks stadium lanjut sangat dipengaruhi oleh respon masing-masing penderita terhadap radiasi, seperti faktor usia, ukuran tumor, jenis histopatologi, keterlibatan organ sekitar, stadium, dan kemoterapi. Metode : Penelitian cohort retrospektif di Departemen Obstetri dan Ginekologi Fakultas Kedokteran Universitas Sumatera Utara – RSUP H. Adam Malik Medan. Maret – Juni 2016. Total sampel berjumlah 104 orang. Kemudian dilakukan uji statistik. Hasil : Didapati adanya hubungan yang bermakna antara respon terapi denganjenis histopatologi dan kemoterapi dimana nilai p< 0,05. Pada penelitian ini juga dinilai resiko hazard dari kemoterapi terhadap respon radiasi mempunyai nilai 4,8 yang berarti pasien dengan kemoterapi lengkap secara signifikan memberikan respon terapi komplit 4,8 kali dibandingkan pasien yang mendapatkemoterapi tidak lengkap. Kesimpulan : Tidak ada hubungan yang bermakna antara respon terapi dengan karakteristik usia, ukuran tumor dan stadium. Hubungan yang bermakna hanya didapati antara respon terapi dengan jenis histopatologi dan kemoterapi.

Introduction: Cancer of the cervix uteri is the 4th most common cancer among women worldwide. The highest incidence rates were in Central and South America, sub-Saharan Africaand Asia. Commonly, patients are in advance stage, Prognosis patient with cervical cancer in advance stage greatly influence by response patient to radiation therapy, such us age, size of tumor, histopathologycal type, organ metastatic, stage of tumor, and administration of chemotherapy. Method : We use retrospective cohort, in Department of Obstetric and Gynecology, Medical School University of North Sumatera/ H. Adam Malik General Hospital along March to June 2016. We had roll and do statistical examination in 104 people as sample. Result: We find any correlation between radiation response with histopatological type and administration of chemoterapy (p<0,05;CI 95%). We also find the Hazard Risk from the chemotherapy is 4,8 so if the patient get the adequate and full chemoterapy will significantly 4,8 times more get complete radiation response compared with the patient who not had full chemotherapy. Conclution: We find no correlation between radiation response with age, size of tumor and stage of cervical cancer. In this research, the correlation is only found on the radiation response with the type of histopathology and administration of chemoterapy.