Perbedaan Kadar Absolut Neutrophil Count (ANC) Terhadap Gambaran Histopatologi pada Penderita Karsinoma Kolorektal di RSUP HAJI Adam Malik Medan

Abstract

Latar belakang : Karsinoma kolorektal merupakan suatu tumor malignansi dengan prevalensi dan mortalitas yang menempati urutan tertinggi ke-empat di Dunia. Peningkatan Absolute Neutrophil Count (ANC) pada pasien karsinoma kolorektal akan mempengaruhi derajat histopatologi karsinoma kolorektal. Tujuan: Penelitian ini bertujuan untuk mengetahui adanya perbedaan kadar Absolute Neutrophil Count (ANC) terhadap gambaran histopatologi pada penderita karsinoma kolorektal di RSUP Haji Adam Malik Medan. Metode: Penelitian ini merupakan penelitian dengan desain studi cross sectional retrospektif. Data diambil dari catatan rekam medis pasien di RSUP Haji Adam Malik Medan. Kemudian dilakukan pencatatan nilai Absolute Neutrophil Count (ANC) dan jenis histopatologinya. Uji statistik yang digunakan adalah uji ANOVA. Hasil : Dari 69 sampel pasien karsinoma kolorektal diperoleh hasil analisis uji ANOVA, kadar ANC Moderate differentiated dan Well differentiated adenocarsinoma p(p-value)=0,222, Poorly differentiated adenocarsinoma dan Well differentiated adenocarsinoma p(p-value)=0,0001, dan Poorly differentiated adenocarsinoma dan Moderate differentiated adenocarsinoma p(p-value)=0,0001. Kesimpulan: Terdapat perbedaan yang signifikan kadar ANC terhadap gambaran histopatologi Poorly differentiated adenocarsinoma dengan Well differentiated adenocarsinoma dan Moderate differentiated adenocarsinoma, sedangkan kadar ANC pada Well differentiated adenocarsinoma dan Moderate differentiated adenocarsinoma tidak terdapat perbedaan pada penderita karsinoma kolorektal di RSUP Haji Adam Malik Medan.

Background: Colorectal carsinoma is a malignant tumor with ranks fourth in prevelancy and mortality in the world. The escalation of absolute neutrophil count (ANC) in patient with colorectal carsinoma will affect the degree of colorectal carsinoma histopathology. Purpose: This research intend to determine the differences Absolute Neutrophil Count (ANC) level against histopathology image in patients with colorectal carsinoma in RSUP Haji Adam Malik, Medan. Methode: It was analytic retrospective studies with cross sectional method. The data taken from medical record in RSUP Haji Adam Malik Medan. Then recorded the value of ANC and the type of the histopahtology. It was analyzed by ANOVA test. Results: The ANOVA test From 69 sample patients with colorectal carsinoma, ANC level Moderate differentiated and Well differentiated adenocarsinoma p(p-values)= 0,222, Poorly differentiated adenocarsinoma and Well differentiated adenocarsinoma p(p-value)= 0,0001, and Poorly differentiated adenocarsinoma and Moderate differentiated adenocarsinoma p(p-value)= 0.0001. Conclusion: There are significant level of ANC against histopathology image Poorly differentiated adenocarsinoma with well differentiated adenocarsinoma and Moderate differentiated adenocarsinoma, while there is no difference between the ANC level at Well differentiated adenocarsinoma and Moderate differentiated adenocarsinoma in patients with colectoral carsinoma in RSUP Haji Adam Malik Medan.