Pengaruh Pemberian Sari Kering Lidah Buaya (Aloe Vera L.) terhadap Profil Lipid Mencit Jantan (Mus Musculus) Strain DD Webster

Abstract

The coronary heart disease in Indonesia seems recently increasing and one of the causes is atherosclerosis. Atherosclerosis is caused by fat which is consumed excessively in food, it can cause hyperlipidemia in the body. Aloe vera L. is one of the Indonesian traditional herbs with effect to decrease the lipid concentration in blood. The aim of this research is to reveal the influence of the treatment with dried Aloe vera L. m decreasing the blood lipid concentration. The method of this research was experimental method, namely as to study or reveal the influence of the treatment with dried Aloe vera L. in decreasing the blood lipid profile of mice with three groups of male mice winch had been made to undergo hyperlipidemia; group I as a control, for group II simvastatin were given, ior group III dried Aloe vera L, were given with dosage A, for group 3V dried Aloe vera L. were given with dosage B, and for group V dried Aloe vera L. were given with dosage C, namely equivalent dosage of 100 mg, 250 mg, and 500 mg for human beings. The influence of the treatment for 14 days of the dried Aloe vera L. indicated the decreasing of the concentration of cholesterol with dosage A 49.67 mg/dl; with dosage B 32.67 mg/dJ and with dosage C 61,17 mg/dl. The influence of the treatment for 14 days of the dried A toe vera L. indicated the decreasing of the concentration of LDL-cholesterol with dosage A 3.S3 mg/dl, with dosage B 3.50 mg/dl, but on the other hand with dosage C indicated the increasing 2,00 mg/dL The influence of the treatment for 14 days of the dried Aloe vera, L. indicated the decreasing of the concentration of HDL-cholcsterol with dosage A 27.34 mg/dl; with dosage B 29,67 mg/dl and with dosage C 30,33 mg/dl. The influence of the treatment for 14 days dried Aloe vera L. indicated the decreasing the concentration of triglyceride with dosage A 137.33 mg'dl; wit it dosage B 127.17 mg/dl and with dosage C 148.67 mg/dh The influence of the treatment for 28 days of the dried Aloe vera L.wiih do sage A 0.33 mg/dJ, with dosage B 10.67 mg/dl and with dosage C 6.67 mg/dl. The influence of the treatment for 2% days indicated the decreasing of the concentration of LDL-cholesterol with dosage A 0.33 mg/di, wth dosage B 9.17 mg/dl, and with dosage C 4.84 mg/dl. The influence of the treatment for 2S days indicated the decreasing of the concentration of HDL-cholesterol with dosage A 1.00 mg/dl, with dosage B 1-17 mg/dl, and with dosage C 1.67 mg/dl. The dreasing of the concentration of triglicerides with dosage B for 2B days indicated the decreasing as much as 2.00 mg/dl, with exception on the treatment as long as 28 days of the dried Aloe vera L. with dosage A indicated the increasing of the concentration of the triglyceride as much as 4 mg/dl and the treatment as long as 28 days of the dried Aloe vera L. with dosage C indicated the increasing of the concentration of the triglyceride as much as 6 mg/di. The results of the decreasing of the concentration of lipid profile with the treatment of the dried Aloe vera L. indicated that the activities were lower if compafred with the treatment with simvastatin. The results of the research of the influence of the treatment as long as 14 days and 28 days of the dried Aloe vera L. with dosages A, B and C indicated the decreasing of the concentration of the lipid profiles of mice. The higher the dose and the longer the time of the treatment, so the lower the concentration of the lipid component would be.

Penyakit jantung koroner di Indonesia pada akhir-akhir ini semakin meningkat dan salah satu penyebabnya adalah aterosklerosis. Aterosklerosis diakibatkan oleh lemak yang dikonsumsi dalam makanan secara berlebihan, di dalam tubuh dapat menyebabkan hiperlipidemia. Lidah buaya adalah salah satu tanaman obat tradisional di Indonesia yang mempunyai manfaat untuk menurunkan kadar lipid dalam darah. Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian sari kering Lidah buaya (Aloe vera L.) untuk menurunkan komponen lipid darah. Metode penelitian ini adalah metode eksperimental yaitu untuk meneliti pengaruh pemberian sari kering lidah buaya {Aloe vera (L) Burm. F.) terhadap profil lipid mencit dengan liga perlakuan kelompok meneit jantan yang telah dibuai hiperiipidemia; kelompok l sebagai kontroL, kelompok II diberi simvastatin, kelompok Il( diberi sari kering Lidah buaya (Aloe vera L.) dosis A, kelompok tVdiberi sari kering Lidah buaya (Aloe vera L.) dosis B, dan kelompok V diberi sari kering Lidah buaya (Aloe vera L.) dosts C yaitu dosis yang setara dengan 100 mg, 250 mg, dan 500 mg pada manusia. Pengaruh pemberian 14 hari terjadi penurunan kadar kolesterol dosis A 49,67 mg/dt, dosis B 32,67 mg/dL dan dosis C 61,17 ntg/dL Pengaruh pemberian 14 hari terjadi penurunan kadar kolesterol-LDI. dosis A 3,83 mg/dl; dosis B 3,50 mg/dl tetapi dosis C terjadi kenaikan 2,00 mg/dl. Pengaruh pemberian 14 hari terjadi penurunan kadar kolestcroI-HDL dosis A 27,34 mg/dl; dosis B 29,67 mg/dl dan dosis C 30,33 mg/dL Pengaruh pemberian 14 hari terjadi penurunan kadar trigliserida dosis A 137,33 mg/dl; dosis B 127,17 mg/dl dan dosis C 148,67 mg/dl. Pengaruh pemberian 2S hari terjadi penurunan kadar kolesterol dosis A 0,33 mg/dl, dosis B 10,67 mg/dl, dan dosis C 6,67 mg/dl. Pengaruh pemberian 28 hari terjadi penurunan kadar kolesterot-LDL dosis A 0,33 mg/dl, dosis B 9,17 mg/dL dan dosis C 4,84 mg/dl. Pengaruh pemberian 28 hari terjadi penurunan kadar kolesterol-HDL dosis A 1,00 mg/dl, dosis B 1,17 mg/dl, dosis C 1,67 mg/dl. Penurunan trigliserida dengan pemberian dosis B selama 28 hari menunjukkan penurunan 2.00 mg/dL kecuali pada pemberian 2 S hari sari kering Lidah buaya dosis A terjadi kenaikan kadar trigliserida 4 mg/dl dan pada pemberian 28 hari sari kering Lidah buaya dosis C terjadi kenaikan kadar trigliserida 6 mg/dl. Hasil penurunan kadar profil lipid dengan pemberian sari kering Lidah buaya (Aloe vera L.) ini daya kerjanya lebih kecil dibandingkan dengan pemberian simvastatin. Hasil penelitian menunjukkan bahwa pengaruh pemberian 14 hari dan 28 hari sari kering Lidah buaya dosis A, dosis B dan dosis C menunjukkan penurunan kadar profil lipid meneit. Semakin linggi dosis dan semakin lama pemberian maka kadar komponen lipid semakin menurun.