| dc.description.abstract | Background: Contrast Induced Nephropathy (CIN) is a serious issue after Percutaneous Coronary
Intervention (PCI) for Acute Myocardial Infarction (AMI) patients. The development of CIN is
associated with increased in-hospital and long-term morbidity and mortality despite succesful early
coronary revascularization. The CHA2DS2-VASC score has been reported recently to predict adverse
clinical outcomes so is CIN in patients with AMI regardless of having atrial fibrillation. We
investigated relationship between CHA2DS2-VASC score with CIN in patients with AMI who
underwent PCI strategies.
Method: This is an ambispective cohort study of 40 patients with AMI who were admited at cardiac
care unit in our centre and underwent PCI. The CHA2DS2-VASC score was calculated for each
patient. From this study 16 cases (40%) with overall prevalence 18.82% of CIN were diagnosed. CIN
was defined as a rise in serum creatinine >0,5 mg/dL or >25% increase in baseline within 24 hours
after PCI.
Results: In the ROC curve analysis, the cut-off value of CHA2DS2-VASC score in the prediction of
CIN was > 3 with a sensitivity of 56.25% and specificity of 87.5% (AUC 0.698, 95%:CI 1.460-
6.163, p=0.003) and has a significant association with CIN (R2 0.485). From multivariate analysis, we
also identified Hb level < 12 mg/dL as an independent predictor of CIN with (RR 3.44, 95%:CI
1.816-6.532, p<0.001).
Conclusion: The CHA2DS2-VASC score was positively associated with CIN. Therefore, it can be
used as a simple and reliable tools to predict CIN in AMI patients who underwent PCI. | en_US |
