Hubungan Derajat Stromal Tumor Infiltrating Lymphocytes (TILs) dengan Total Prostate Specific Antigen (tPSA) pada Benign Prostate Hyperplasia (BPH) dan Adenokarsinoma Prostat

Abstract

Background: Prostate disorders are one of the main causes of quality of life disorders in men. Since 1994, the total PSA value has been approved by the United States Food and Drug Administration (FDA) as a marker of early detection, determining the stage and prognosis in prostate cancer. Many studies have reported the benefits of tumor-infiltrating lymphocytes (TILs) in tumor cells, where TILs are effective in slowing progression, although the mechanism is still opposite . Objective: To assess the correlation between the degrees of Stromal TILs with Total PSA in BPH and Prostate Adenocarcinoma Methods: 32 of histopathological slides of BPH and prostate adenocarcinoma were examined to assess the degree of stromal TILs. Age characteristics and Total PSA values were obtained through medical records. The relationship degree of Stromal TILs with Total PSA was analyzed using SPSS version 22. Results and Discussion: The results of analysis showed that there was a significant correlation between the degree of stromal TILs and total PSA on BPH and Prostate Adenocarcinoma. Inflammatory are commonly associated with neoplasms, where TILs play a role as a tumor cell defense factor, which often appears in solid tumors, including prostate. Reduce a number of inflammatory cells in the prostate indicates a worse prognosis in prostate malignancy. Conclusion: Percentage of stromal TILs and value of total PSA can be used to determine prognostic factors in BPH and prostate adenocarcinoma.

Latar Belakang: Kelainan prostat merupakan salah satu penyebab utama dari gangguan kualitas hidup pada laki-laki. Sejak tahun 1994, nilai Total PSA telah disahkan oleh Food and Drug Administration (FDA) Amerika Serikat sebagai marker deteksi dini, menentukan stadium dan prognosis pada kanker prostat. Banyak penelitian yang melaporkan keuntungan Tumor Infiltrating Lymphocytes (TILs) pada sel tumor, dimana TILs ini efektif untuk memperlambat progresi tumor, meskipun mekanismenya masih berlawanan Tujuan: Menilai hubungan derajat stromal Tumor Infiltrating Lymphocytes (TILs) dengan total Prostate Specific Antigen (tPSA) pada BPH dan Adenokarsinoma Prostat. Metode: 32 slide histopatologi penderita BPH dan Adenokarsinoma Prostat dinilai derajat stromal TILs nya. Nilai Total PSA didapatkan melalui rekam medis. Hubungan derajat stromal Tumor Infiltrating Lymphocytes (TILs) dengan total Prostate Specific Antigen (tPSA) dianalisis menggunakan SPSS versi 22. Hasil dan Diskusi: Terdapat hubungan yang signifikan antara derajat stromal Tumor Infiltrating Lymphocytes (TILs) dan total Prostate Spesific Antigen (tPSA) pada BPH dan Adenokarsinoma Prostat, dimana menurunnya derajat stromal TILs diikuti oleh peningkatan nilai total PSA. Sel inflamasi umumnya berkaitan dengan neoplasma, dimana limfosit berperan sebagai faktor pertahanan sel tumor, yang sering muncul pada tumor solid, termasuk prostat. Berkurangnya jumlah sel radang pada prostat menunjukkan prognosis yang lebih buruk pada keganasan prostat. Simpulan: Penilaian stromal TILs dan total PSA dapat digunakan untuk menentukan faktor prognosis pada BPH dan Adenokarsinoma Prostat.