Hubungan Antara Neutrophyl-To-Lymphocyte Ratio (NLR) dengan Jumlah Lesi Arteri Koroner pada Pasien Sindroma Koroner Akut

Abstract

Acute Coronary Syndrome (ACS) is the leading cause of death from cardiovascular disease. ACS is an abnormal condition caused by cardiac dysfunction and narrowing of the coronary arteries. Narrowing of the coronary arteries in the pathophysiology of ACS involves the process of atherosclerosis. It is important to assess early whether there are coronary artery lesions or not. Neutrophyl-to-lymphocyte Ratio (NLR) is a simple ratio between neutrophils and lymphocytes that can be obtained from routine blood tests and is known to be related to the severity of coronary artery lesions. This research is a retrospective research on 61 samples obtained through consecutive sampling between January- December 2018 at H. Adam Malik General Hospital, Medan. Data obtained from medical records of patients where NLR levels were found from routine blood results and the number of coronary artery lesions found from the results of the patient's coronary angiography. All data were collected and analyzed using SPSS version 22. Based on data analysis, we found that there’s a significant relationship between NLR levels and the number of coronary artery lesions in ACS patients with p = 0.004

Sindroma Koroner Akut (SKA) nerupakan penyebab utama kematian akibat penyakit kardiovaskular. SKA merupakan keadaan abnormal yang disebabkan oleh disfungsi jantung dan penyempitan pembuluh darah koroner. Penyempitan pembuluh darah koroner melibatkan proses aterosklerosis pada arteri koroner mendasari terjadinya SKA. Penting untuk menilai secara dini ada tidaknya lesi arteri koroner. Neutrophyl-to-lymphocyte Ratio (NLR) merupakan rasio sederhana antara neutrophil dan lymphocyte yang bisa didapat dari hasil pemeriksaan darah rutin serta diketahui berhubungan dengan derajat keparahan lesi arteri koroner. Penelitian ini bersifat retrospektif terhadap 61 sampel yang didapatkan melalui consecutive sampling pada bulan Januari-Desember 2018 di RSUP H. Adam Malik Medan. Data didapatkan dari rekam medis pasien dimana kadar NLR didapati dari hasil darah rutin dan jumlah lesi arteri koroner didapati dari hasil angiografi koroner pasien. Seluruh data dikumpulkan dan dianalisa dengan SPSS versi 22. Berdasarkan analisa data didapati hubungan yang signifikan antara kadar NLR dengan jumlah lesi arteri koroner pada pasien SKA dengan nilai p = 0.004.