Pengaruh Kadar Tumor Necrosis Factor-Alpha Serum dengan Penyakit Perlemakan Hati Non-Alkoholik

Abstract

Latar Belakang: Kondisi perlemakan hati terjadi dikarenakan adanya penambahan asam lemak bebas dihati.Hal ini akan menimbulkan peningkatan oksidasi dan esterifikasi lemak.Ketika kondisi stres oksidatif di hati melebihi kemampuan perlawanan antioksidan, maka aktivasi sel stelata dan sitokin proinflamasi akan berlanjut dengan inflamasi progresif. TNF-ɑ merupakan salah satu sitokin pro-inflamasi yang mengalami peningkatan signifikan pada kondisi NAFLD Tujuan: Mengetahui perbedaan kadar TNF-α antara pasien NAFLD dan kelompok kontrol Metode: Studi potong lintang terhadap 30 pasien NAFLD secara konsekutif yang datang ke Rumah Sakit Umum Adam Malik Medan dari April–September 2018. Penilaian NAFLD menggunakan ultrasonografi. Analisis univariat, bivariat (uji Chi-square dan fisherexact) dengan SPSS versi22. Hasil: Pada grup NAFLD memiliki nilai median TNF-α3,18 pg/ml dan pada grup kontrol dengan nilai median1,72 pg/ml.Terdapat perbedaan yang signifikan nilai TNF-α antara grup NAFLD dengan grup kontrol (p=0,0001). Kesimpulan: Terdapat perbedaan yang signifikan kadar TNF-α antara grup NAFLD dengan kontrol.Dimana kadar TNF-α serum lebih tinggi pada grup NAFLD dibandingkan dengan grup kontrol

Introduction:Fatty liver disease is the addition of free fatty acids in liver. This causes an increase in fat oxidation and esterification. When the oxidative stress condition in the liver exceeds the ability of anti-oxidants, it will activate stellate cells and pro-inflammatory cytokines which leads to a progressive inflammatory process. TNF-ɑ is a pro-inflammatory cytokine that experiences a significant increase in NAFLD. Aim: To investigate correlation of TNF-α serum level in Non-Alcoholic Fatty Liver Disease Method: This study was a cross-sectionalstudy with a total of 30 NAFLD patients who came to Adam Malik General Hospital Medan, from April to September 2018. Assessment for NAFLD was done by ultrasound imaging. A univariate and bivariate(Chi-square and fisher exact test) analysis were performed using the SPSS version 22. Results: Median value of TNF-α in the NAFLD group was 3.18 pg/ml and 1.72 pg/ml in the control. There is a significant difference of TNF-α levels between the NAFLD and control group (p=0.0001). Conclusion:There were significant association between blood glucose levels, lipid profile, liver function test, TNF-ɑ level and NAFLD patient as well as its control.