Kadar Red Cell Distribution Width (RDW), Platelet Distribution Width (PDW), Hitung Limfosit – Monosit pada Sepsis

Abstract

Pendahuluan Red cell distribution width (RDW), adalah variabilitas dalam ukuran eritrosit PDW adalah ukuran variasi dalam ukuran trombosit, Limfosit-monosit adalah jenis sel darah putih yang memiliki fungsi penting dalam sistem kekebalan tubuh. Red cell distribution width (RDW), Platelet distibution Width (PDW), Hitung limfosit-monosit yang merupakan bagian dari panel pemeriksaan darah lengkap, sering dilakukan untuk mengevaluasi beberapa penyebab sepsis. Untuk menilai tingkat keparahan penyakit berdasarkan derajat disfungsi organ secara serial setiap waktu digunakan suatu skor yaitu Sequential Organ Failure Assessment (SOFA). Tujuan penelitian ini adalah untuk melihat hubungan RDW, PDW hitung limfosit-monosit dengan skor SOFA pada pasein sepsis. Metode Desain penelitian secara cross sectional. 30 pasien yang mengalami sepsis yang memenuhi kriteria inklusi dan ekslusi dilibatkan dalam penelitian ini. Sampel yang di dapat dilakukan pengukuran RDW, PDW dan hitung monosit-limfosit dan perhitungan skor SOFA, yang dianalisa dengan uji Spearman Test. Hasil dan Pembahasan Kadar Limfosit dan monosit terdapat hubungan yang signifikan dengan skor SOFA dengan (r = 0.760 dan p = 0,001). Ada korelasi keparahan perjalanan klinis dan beratnya limfositopenia Kesimpulan dan Saran Penelitian menunjukkan adanya hubungan antara Kadar Limfosit-monosit terdapat hubungan dengan skor SOFA. Semakin menurun kadar limfosit maka semakin meningkat pula skor SOFA. Limfosit dan monosit dapat dipakai dipertimbangkan sebagai parameter untuk deteksi sepsis.

Bacground Red cell distribution width (RDW), is the variability in erythrocyte size PDW is a measure of variation in platelet size, Lymphocytes are a type of white blood cell has an important function in the immune system. Red cell distribution width (RDW), Platelet distibution Width ( PDW), Count lymphocytes - monocytes a complete blood examination panel, often performed to evaluate several causes of sepsis. To assess the severity of the disease based on the degree of organ dysfunction serially each time a score is used, namely Sequential Organ Failure Assessment (SOFA). The purpose of this study was to look at the relationship of RDW, PDW lymphocyte-monocyte count with SOFA scores in patients with sepsis. Method The study design was cross sectional. 30 patients who experienced sepsis who met the inclusion and exclusion criteria were included in this study. Samples obtained were measured by RDW, PDW and monocyte-lymphocyte count and SOFA score calculation, which was analyzed by the Spearman Test. Results and Discussion Lymphocyte and monocyte levels have a significant relationship with SOFA scores with (r = 0.760 and p = 0.001). There is a correlation between the severity of clinical course and the severity of lymphocytopenia Conclusions Research shows that there is a relationship between lymphocyte-monocyte levels, there is a relationship with SOFA score. The decreased levels of lymphocytes the SOFA score also increases, Lymphocytes and monocytes can be considered as parameters for the detection of sepsis