Pola Resistensi Primer pada Penderita TB Paru Kategori I di RSUP H. Adam Malik Medan

Abstract

ABSTRACT Backgrounds : The resistance case is a problem for TB prevention and eradication program of the world. Primary resistance cases that was founded in TB patients are often used to evaluate new transmission or infection resistant strains of bacteria. Therefore, it is important to investigate how much the rate and the pattern of primary resistance. Objective : To evaluation the proportion of primary resistance incidence in category I of pulmonary TB patients in H. Adam Malik Hospital, Medan-Indonesia. Method : This research is a retrospective cross-sectional descriptive study. Data retrieved from medical records with a time span of October 2010 until July 2011. Subjects were patients with no history of antituberculosis drugs treatment or ever consumed less than 1 month. Subjects research conducted direct smear examination of sputum, cultur and sensitivity test before getting treatment antituberculosis drugs then collected data on demographics, chief complaint, history of use of antituberculosis drugs, and Chest X-ray radiology data. Results : From 85 research subjects, we obtained 35 subjects (41.18%) with primary resistance. Primary mono-drug resistance as many as 18 subjects (21.18%), where the highest resistance to the drugs Streptomycin (S) of 10 subjects (11,76%). Incidence of primary poly-drug resisten by 13 subjects (15.27%), mostly on the type of combination of Streptomycin and Ethambutol (SE) of 4 subjects (4.70%). Primary MDR-TB by 4 research subjects (4.71%). Conclusion : The primary resistance rate is high in patients with pulmonary tuberculosis category I in H. Adam Malik Hospital, Medan, Indonesia. So, it is necessary to improve the vigilance and efforts in primary resistance management. Keywords : Primary Mono-drug Resistance, Primary Poly-drug Resistance, Primary MDR-TB