Perbandingan Efek Pemberian Kombinasi Ekstrak Sambiloto (Andrographis paniculata (Burm.f.) Nees) dan Daun Salam (Syzygium polyanthum (Wight) Walp) dengan Simvastatin Terhadap Kadar hs-CRP pada Pasien Dislipidemia

Abstract

Introduction: Dyslipidemia is risk factor of cardiovascular disease and significantly correlated with increased hs-CRP concentration. Simvastatin, a sintetic antidyslipidemic drug, can decrease hs-CRP concentration. But long term use of sintetic drug may cause side effects, so that phytopharmaca is begin to reuse. Combination sambiloto extract and salam could decrease proinflammatory cytokines, cholesterol, and triglyceride. Aim of this study was to compare the effect of combination sambiloto extract and salam with simvastatin on hs-CRP concentration in dyslipidemic patients. Method: This clinical trial use prospective design. Study group (n = 15) and control group (n = 15) were choosen with double blind random sampling. Before and after 30 days theraphy, blood sample was taken. Data was analysed with SPSS, if p < 0,05 was considered significant difference. Result: Before and after 30 days theraphy was there was significant decrease of mean hs-CRP ((3,02 + 3,13 vs 1,67 + 1,37) mg/dL; p = 0,005) in study group; meanwhile insignificant decrease ((2,78 + 1,97 vs 2,25 + 2,32) mg/dL; p = 0,285) was there in control group. hs-CRP decrease of study group was biger than that of control group, but statistically insignificant ((1,35 + 2,37 vs 0,53 + 1,96) mg/dL; p = 0,089 mg/dL). Conclusion: Combination sambiloto extract (Andrographis paniculata) and salam (Syzygium polyanthum) 2 x @ 150 mg for 30 days decreased hs-CRP concentration biger than simvastatin 1 x 20 mg, but statistically insignificant

Introduction: Dyslipidemia is risk factor of cardiovascular disease and significantly correlated with increased hs-CRP concentration. Simvastatin, a sintetic antidyslipidemic drug, can decrease hs-CRP concentration. But long term use of sintetic drug may cause side effects, so that phytopharmaca is begin to reuse. Combination sambiloto extract and salam could decrease proinflammatory cytokines, cholesterol, and triglyceride. Aim of this study was to compare the effect of combination sambiloto extract and salam with simvastatin on hs-CRP concentration in dyslipidemic patients. Method: This clinical trial use prospective design. Study group (n = 15) and control group (n = 15) were choosen with double blind random sampling. Before and after 30 days theraphy, blood sample was taken. Data was analysed with SPSS, if p < 0,05 was considered significant difference. Result: Before and after 30 days theraphy was there was significant decrease of mean hs-CRP ((3,02 + 3,13 vs 1,67 + 1,37) mg/dL; p = 0,005) in study group; meanwhile insignificant decrease ((2,78 + 1,97 vs 2,25 + 2,32) mg/dL; p = 0,285) was there in control group. hs-CRP decrease of study group was biger than that of control group, but statistically insignificant ((1,35 + 2,37 vs 0,53 + 1,96) mg/dL; p = 0,089 mg/dL). Conclusion: Combination sambiloto extract (Andrographis paniculata) and salam (Syzygium polyanthum) 2 x @ 150 mg for 30 days decreased hs-CRP concentration biger than simvastatin 1 x 20 mg, but statistically insignificant