Korelasi News 2 dan Biomarker Inflamasi NLR, CRP, Il-6 terhadap Derajat Penyakit Pasien Covid-19 di RSUP Haji Adam Malik Medan

Abstract

Pendahuluan: Coronavirus Disease 19 (COVID-19) adalah penyakit yang dapat menyebabkan serangkaian proses inflamasi dalam patogenesitasnya. C-reactive protein (CRP), interleukin 6 (IL-6), neutrophile lymphocyte ratio (NLR), dan National Early Warning Score (NEWS) 2 adalah beberapa dari banyak parameter yang dipertimbangkan dalam penggunaannya pada penyakit ini. Tujuan: Menggambarkan nilai NEWS2, CRP, IL-6, dan NLR, serta mencari korelasinya terhadap derajat penyakit COVID-19 Metode: Penelitian ini melibatkan 47 orang sampel, dan dilakukan penghitungan NEWS2, pemeriksaan IL-6, CRP, serta penilaian risiko berdasarkan NEWS2 terhadap pasien terkonfirmasi COVID-19 di RSUP HAM Hasil: Terdapat korelasi antara NEWS2 (rho 0.265, p 0.360) dan IL-6 (rho -0.340, p 0,010) dengan derajat penyakit COVID-19 (CI 95%, p < 0.05). Tidak ada korelasi yang ditemukan antara NLR dan CRP dengan derajat penyakit COVID-19. Kesimpulan: terdapat korelasi antara NEWS2 dan IL-6 tehadap derajat penyakit COVID-19.

Introduction: Coronavirus Disease 19 (COVID-19) is a disease that can cause a series of inflammatory processes in its pathogenesis. C-reactive protein (CRP), interleukin 6 (IL-6), neutrophile lymphocyte ratio (NLR), and National Early Warning Score (NEWS) 2 are some of the many parameters considered in their use in this disease. Aim: Describing the values of NEWS2, CRP, IL-6, and NLR, and analyzing their correlation to the degree of COVID-19 severity. Method: This study involved 47 samples, and carried out the calculation of NEWS2, examination of IL-6, CRP, as well as risk assessment based on NEWS2 of patients with confirmed COVID-19 at RSUP HAM. Result: There was a correlation found between NEWS2 (rho 0.265, p 0.360), IL-6 (rho -0.340, p 0.010) and the severity of COVID-19 disease (95% CI, p < 0.05). No correlation was found between NLR and CRP with the degree of COVID-19 disease. Conclusion: There is a correlation between NEWS2 and IL-6 on the degree of COVID-19 severity.