Hubungan Kadar Serum 25-Hydroxyvitamin-D dengan Indeks Scoring Of Atopic Dermatitis (SCORAD) Pada Anak Dermatitis Atopik

Abstract

Background: Vitamin D plays an important role in immune system, where vitamin D inhibits B lymphosite proliferation and modulates humoral immunity response to suppressed IgE production. Recent studies about correlation between serum 25-hydroxyvitamin-D level and severity of atopic dermatitis in several countries had shown varying result. Objective: To determind the correlation between serum 25-hydroxyvitamin-D level and the scoring of atopic dermatitis index in children. Methods: A cross sectional study was conduct among 26 children with atopic dermatitis from September 2015 until December 2015. We evaluated the severity of disease using the Scoring of Atopic Dermatitis ( SCORAD ) index. The serum 25-hydroxyvitamin-D level was obtained from laboratory. Spearman test was used to analyse the correlation between serum 25-hydroxyvitamin-D level and the scoring of atopic dermatitis in children with atopic dermatitis. Results: Mean (SD) of the SCORAD Index was 32.0 (14.99) , with the lowest score 10.9 and the higher score 71.4 . Mean (SD) of the serum 25-hydroxyvitamin-D level was 41,06 ± 24.81, with the lowest level 10 and the higher level 137. There was a moderate correlation between the serum 25-hydroxyvitamin-D level and the SCORAD Index (r =-0.591) with the higher SCORAD index the lower serum 25-hydroxyvitamin-D level (p=0.01) Conclusion: There was a moderate correlation between the serum 25-hydroxyvitamin-D level and the SCORAD Index in children with atopic dermatitis

Latarbelakang: Vitamin D memiliki peranan pada sistem imun, dimana vitamin D berperan menghambat proliferasi limfosit B dan memodulasi respons imun humoral sehingga sekresi imunoglobulin berkurang. Banyak studi yang menilai hubungan kadar serum 25-Hydroxyvitamin-D terhadap tingkat keparahan DA di negara – negara Eropa, Amerika dan Asia. Namun hasil studi tersebut menunjukkan hasil yang berbeda. Tujuan: untuk mengetahui hubungan kadar serum 25-hydroxyvitamin-D dengan indeks Scoring of atopic Dermatitis ( SCORAD ) pada anak dengan dermatitis atopik? Metode: penelitian cross sectional pada 26 orang anak dermatitis atopik dilaksanakan bulan September 2015 – Desember 2015, dilakukan penilaian Indeks SCORAD dan pemeriksaan kadar serum 25-Hydroxyvitamin-D. Korelasi kadar serum 25-Hydroxyvitamin-D dengan indeks SCORAD digunakan uji korelasi spearman. Hasil: Rerata Indeks SCORAD subyek penelitian adalah 32 dengan simpang baku 14.99, nilai terendah dan tertinggi masing-masing adalah 10.9 dan 71.4. Kadar Serum 25-hydroxyvitamin-D diperoleh nilai rerata 41,06 dengan simpangan baku 24.81, kadar terendah dan tertinggi masing-masing adalah 10 dan 137. Ditemukan korelasi yang signifikan antara kadar serum 25-hydroxyvitamin-D dan Index Scorad (r = -0.591). Korelasi yang terbentuk adalah korelasi negatif yang bersifat sedang yaitu semakin tinggi nilai indeks SCORAD maka semakin rendah kadar serum 25-hydroxyvitamin-D (p=0.01). Kesimpulan: Pada penelitian ini didapatkan korelasi negatif yang bersifat sedang antara kadar serum 25-hydroxyvitamin-D dan indeks SCORAD.