Hubungan Kadar Adrenocorticotropine Hormone dan Enzim 11 Β-Hydroxylase dengan Profil Lipid Serum pada Obesitas, Overweight dan Normal

Abstract

Background: Some studies had suggested that obesity correlate with lipid profile disturbance. The hypothalamic-pituitary-adrenal (HPA) axis has been assumed to be involved in obesity-associated lipid profile disturbance. The aim of this study was to investigate the association between adrenocorticotopic hormone (ACTH) and 11 β-Hydroxylase levels and lipid profile in young men. Methods: This case-control study of 75 18-28 years old men which is divided in three groups (obese, overweight, and normal) was performed at HKBP Nommensen University Medan. ACTH, 11 β-Hydroxylase, and lipid profile (total cholesterol, HDL cholesterol, LDL cholesterol, and triglycerides) was evaluated in blood sample. The data was analyzed bivariately and multivariately. Results: Lipid profile of young obese men was worse than normal men (p < 0.05). ACTHand 11 β-Hydroxylase levels of young overweight men was higher than normal men (p < 0.05), but there was no difference of ACTHand 11 β- Hydroxylase levels between young obese and normal men statistically (p > 0.05). ACTH level positively correlate with LDL cholesterol level (p= 0.039). Linear regression testing showed that 11 β-Hydroxylase level affected total cholesterol level (p= 0.008). Conclusions: HPA axis activity is raised in overweight young men. ACTH level is positively correlate with LDL cholesterol, 11 β-Hydroxylase level affected total cholesterol level. These data shows that HPA axis play a role in lipid metabolism disturbance in obesity and overweight young men.

Latar Belakang: Beberapa penelitian telah membuktikan bahwa obesitas berhubungan dengan gangguan profil lipid. Gangguan profil lipid pada obesitas diduga terjadi melalui hiperaktivitas aksis hypothalamic-pituitary-adrenal (HPA). Penelitian ini bertujuan untuk mengetahui hubungan antara adrenocorticotropine hormone (ACTH) dan 11 β-Hydroxylase dengan profil lipid pada laki-laki usia muda. Metode: Penelitian kasus kontrol terhadap 75 laki-laki usia 18-28 tahun yang dibagi menjadi tiga kelompok (obesitas, overweight, dan normal) dilakukan di Universitas HKBP Nommensen Medan. ACTH, 11 β-Hydroxylase, dan profil lipid (kolesterol total, HDL, LDL, dan trigliserida) diperiksa dari sampel darah subyek penelitian.Analisis data dilakukan secara bivariat dan multivariat. Hasil: Laki-laki usia muda yang obesitas memiliki kecenderungan profil lipid lebih buruk dibanding dengan normal (p < 0,05). Kadar ACTH dan11 β- Hydroxylase kelompok overweight lebih tinggi dibandingkan normal (p < 0,05), namun kadar ACTH dan 11 β-Hydroxylase kelompok obesitas secara statistik tidak berbeda secara signifikan dengan normal (p > 0,05). Kadar ACTH berkorelasi positif dengan kadar kolesterol LDL (p = 0,039). Hasil uji regresi linear menunjukkan kadar11 β-Hydroxylase berpengaruh terhadap kadar kolesterol total (p = 0,008). Kesimpulan: Peningkatan aktivitas aksis HPA sudah terlihat pada laki-laki usia muda yang overweight. Kadar ACTH didapatkan berkorelasi positif dengan kolesterol LDL, dan 11 β-Hydroxylase berpengaruh terhadap kolesterol total. Hal ini menunjukkan bahwa aksis HPA berperan dalam gangguan metabolisme lipid pada laki-laki usia muda obesitas dan overweight.