Korelasi kadar feritin serum dengan derajat keparahan sirosis hati berdasarkan skor Model for End Stage Liver Disease (MELD) dan Child Turcotte Pugh (CTP)

Abstract

Background: Serum ferritin is a known marker of hepatic necro-inflammation that has been shown to independently predict poor clinical outcomes. The aim of this study was to assess the correlation between serum ferritin and severity of liver cirrhosis, as assessed by Model for End Stage Liver Disease (MELD) and Child Turcotte Pugh (CTP) score. Methods: Adults liver cirrhosis patients admitted at Adam Malik Hospital Medan during May 2016 - May 2017, were included in this study. Results: A total of 54 patients were enrolled. Majority of cases of liver cirrhosis are due to chronic viral hepatitis B infections (53.7 %). Elevated serum ferritin level was associated with mortality (p =0.024) and showed significant correlation with MELD score (r = 0.534, p =0.000), CTP score (r = 0.487, p =0.000). Conclusion: Serum ferritin levels correlate with severity of liver cirrhosis and are associated with mortality.

Latar Belakang: Feritin serum diketahui sebagai marker nekroinflamasi hati dan merupakan prediktor independen terhadap prognosis yang buruk terhadap suatu penyakit. Tujuan dari penelitian ini adalah untuk meneliti Korelasi kadar feritin serum dengan derajat keparahan sirosis hati berdasarkan skor Model for End Stage Liver Disease (MELD) dan Child Turcotte Pugh (CTP). Metode penelitian: Sampel penelitian adalah penderita sirosis hati yang dirawat di Rumah Sakit Adam Malik Medan dari Bulan Mei 2016 sampai Mei 2017. Hasil : Dari 54 pasien sirosis hati yang termasuk dalam penelitian ini, penyebab utama dari sirosis hati adalah infeksi hepatitis B kronik (53.7%). Tingginya kadar feritin serum berhubungan dengan Mortalitas (p =0.024) dan terdapat korelasi yang signifikan antara feritin serum dengan skor MELD (r = 0.534, p =0.000), dan skor CTP (r = 0.487, p =0.000). Kesimpulan: Kadar feritin serum berkorelasi dengan derajat keparahan sirosis hati dan berhubungan dengan mortalitas.